Investigating Disease Mechanism In Adamantinomatous Craniopharyngioma Using New Cell Line Models

Adamantiomatious craniopharyngioma (ACP) is an intracranial tumor that is histologically benign, but the clinical manifestation of the disease can have profound effects due to the location of the tumor. Current understanding of the disease pathology is limited and there are no targeted drug therapeutics for the disease. The lack of reliable cell line models for ACP has limited researcher’s ability to utilize techniques to study disease mechanisms and drug interactions. In this study, researchers propose to characterize and validate the new ACP tumor cell lines developed and provided by the Children’s Brain Tumor Network. The goal of this project is to characterize and validate the cell line model for use as reliable in-vitro models of ACP. Once established, this model can be utilized to great extent in the laboratory to explore disease mechanisms and drug interactions of ACP. Access to matched samples and curated database of clinical, histological, and molecular information associated with these cell lines that is available from the Children’s Brain Tumor Network is very critical for the success of this project.