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specimen

Maternal Microchimerism in Human Brain

Lead Researcher
J Lee Nelson, MD
Lead Institution
Fred Hutchinson Cancer Research Center
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specimen

Understanding the effect of mismatch repair deficiency on the alternative lengthening of telomeres

Lead Researcher
Roger Greenberg
Lead Institution
University of Pennsylvania
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specimen

Genetic Susceptibility to Medulloblastoma

Lead Researcher
Maral Adel Fahmideh, PhD
Lead Institution
Baylor College of Medicine
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specimen

Genomic Analysis of Oligodendrogilomas across the pediatrics, adolescents and adults

Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Evaluation of immunosignature profile in medulloblastoma

Lead Researcher
Mateusz Koptyra, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Development of Preclinical Models of Pediatric Ependymoma

Lead Researcher
Ching Lau, MD, PhD
Lead Institution
Jackson Laboratory for Genomic Medicine
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data

Center for Pediatric Tumor Cell Atlas

Lead Researcher
Kristina Cole, MD, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Mechanisms of medulloblastoma formation

Lead Researcher
Erwin Van Meir, PhD
Lead Institution
UAB - Children's of Alabama
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specimen

Rapid Molecular Central Nervous System Tumor Diagnosis

Lead Researcher
Peter Madsen, MD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Molecular and Spatial Insights into Treatment Failure in Pediatric Low-Grade Gliomas

Lead Researcher
Ana Guerreiro Stücklin, MD, PhD
Lead Institution
University Children’s Hospital Zürich
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specimen

Leveraging Deep Learning to Decipher Single-cell Epigenetic Regulation in Diffuse Midline Glioma and Ependymoma

Lead Researcher
Yang Li, PhD
Lead Institution
Washington University School of Medicine
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specimen

Systems biology integration of single-cell and spatial omics data to dissect tumor and tumor microenvironment interaction map of atypical teratoid rhabdoid tumors.

Lead Researcher
Jiyang Yu, PhD
Lead Institution
St. Jude Children's Research Hospital
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specimen

The Proteomic Landscape of Low-Grade Glioma (LGG)

Lead Researcher
Roger Reddel, MD, BSc (Med), MBBS, FRACP, FAAHMS, FAA
Lead Institution
Children's Medical Research Institute
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specimen

Medulloblastoma subgroups stratification using transcriptome and RNA modification landscape

Lead Researcher
Stacie Stapleton, MD
Lead Institution
Johns Hopkins All Children’s Hospital
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specimen

An immuno-epigenomic approach to identify therapeutic opportunities for Paediatric High-Grade Gliomas

Lead Researcher
Claire Sun
Lead Institution
Hudson Institute of Medical Research
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data

ENPP1 inhibition in models of medulloblastoma

Lead Researcher
Sunil Sharma / Stingray
Lead Institution
The Translational Genomics Research Institute (TGen)
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specimen

Investigating disease mechanism in Adamantinomatous Craniopharyngioma using new cell line models.

Lead Researcher
Todd Hankinson, MD
Lead Institution
Children's Hospital Colorado/ University of Colorado Anschutz Medical Campus
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specimen

Genomic Analysis of Chordomas across the pediatrics, adolescents and adults

Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Therapeutic targeting of the blood-brain barrier in pediatric malignant brain tumors

Lead Researcher
Sadhana Jackson, MD
Lead Institution
National Institutes of Health (NIH)
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specimen

Targeting medulloblastoma by regulating RNA binding proteins

Lead Researcher
Robert Schnepp
Lead Institution
Emory University
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specimen

Regional Response to ONC201 in Pediatric High-Grade Glioma

Lead Researcher
Carl Koschmann, MD
Lead Institution
University of Michigan
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specimen

Impeding LIN28 function in ATRT

Lead Researcher
Giselle Saulnier Sholler, MD
Lead Institution
Helen DeVos Children's Hospital
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specimen

Identification of circulating noncoding RNAs and metabolites in cerebrospinal fluid (CSF) in medulloblastoma patients

Lead Researcher
Ranjan Perera, PhD
Lead Institution
Johns Hopkins Medicine
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specimen

Targeting regions of converging synteny in pediatric and canine glioma

Lead Researcher
Roel Verhaak, PhD
Lead Institution
Yale University
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specimen

Investigating the Metabolic Hallmarks of Oligodendroglioma

Lead Researcher
Samuel McBrayer, PhD
Lead Institution
University of Texas Southwestern Medical Center
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specimen

Identifying the cells of origins of brain tumors using somatic mutations

Lead Researcher
Gilad Evrony, MD, PhD
Lead Institution
Hassenfeld Children’s Hospital at NYU Langone
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specimen

Delineating pediatric glioma progression using single-nuclei sequencing

Lead Researcher
Trevor Pugh, PhD, FACMG
Lead Institution
University Health Network
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specimen

Personalized therapy for high-risk ependymoma of childhood

Lead Researcher
Vijay Ramaswamy, MD, PhD, FRCPC
Lead Institution
The Hospital of Sick Children (Sick Kids)
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specimen

Microglial Mosaicism in BRAFV600E Glioma

Lead Researcher
Estibaliz Lopez-Rodrigo, MD
Lead Institution
Memorial Sloan Kettering Cancer Center
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specimen

CBTTC cell lines high throughput drug screening study

Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Oncolytic virus to potentiate immune-checkpoint blockade in immunologically cold brain tumors

Lead Researcher
Aaron Diaz, PhD
Lead Institution
UCSF Benioff Children’s Hospital
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specimen

Pediatric brain tumor miRNA profiling for the cohort of Children’s Brain Tumor Tissue Consortium specimens

Lead Researcher
Mateusz Koptyra, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Exploring the possible role of mutations in MTOR pathway genes in the pathogenesis of DNET tumors.

Lead Researcher
Anna Maria Buccoliero M.D, PhD
Lead Institution
Meyer Children’s Hospital
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specimen

Disclosing chromatin accessibility in brain tumor cells after treatment by cracking a ‘nucleosomal code’

Lead Researcher
Jakub Mieczkowski, PhD
Lead Institution
Nencki Institute of Experimental Biology Polish Academy of Sciences
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specimen

Molecular Analysis of the Cellular Ecosystem of Childhood Ependymoma

Lead Researcher
Pablo Gonzalez-Camara, PhD
Lead Institution
University of Pennsylvania
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specimen

GPC2 as an immunotherapeutic target in medulloblastoma and other pediatric brain tumors

Lead Researcher
Jessica Foster, MD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Interactions between astrocytes and tumor cells are critical for medulloblastoma growth

Lead Researcher
Zeng-Jie Yang, MD, PhD
Lead Institution
Fox Chase Cancer Center
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specimen

Cracking the Histone Code: Characterizing Pediatric Brain Tumor Epigenetics using Cerebrospinal Fluid

Lead Researcher
Amanda M. Saratsis, MD
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
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specimen

Elucidating the somatic epigenetic landscape of pediatric meningioma and schwannoma

Lead Researcher
Sameer Agnihotri, PhD
Lead Institution
UPMC Children’s Hospital of Pittsburgh
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specimen

Molecular and functional characterization of childhood supratentorial ependymoma

Lead Researcher
Vijay Ramaswamy, MD, PhD, FRCPC
Lead Institution
The Hospital of Sick Children (Sick Kids)
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specimen

Germline and somatic determinants of paediatric brain tumor evolution

Lead Researcher
Sorana Morrissy, PhD
Lead Institution
University of Calgary
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specimen

Elucidating the role of driver mutations in pediatric High Grade Glioma

Lead Researcher
Thomas De Raedt, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Elucidate potential therapeutic targets in H3.3G34 mutant pHGG cells

Lead Researcher
Zhiguo Zhang, PhD
Lead Institution
Columbia University
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specimen

Defining the role of the histone 3 (H3.3G34R) mutation in the pathogenesis of pediatric high astrocytoma

Lead Researcher
Cynthia Hawkins, MD, PhD
Lead Institution
The Hospital of Sick Children (Sick Kids)
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specimen

Released Tumor DNA in the CSF for the Diagnosis and Monitoring of Pediatric Brain Tumors

Lead Researcher
Chetan Betagowda, MD, PhD
Lead Institution
Johns Hopkins Medicine
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specimen

Using whole genome bisulfite sequencing to identify novel therapeutic targets in DIPG and ATRT

Lead Researcher
Eric Raabe, MD, PhD
Lead Institution
Johns Hopkins Medicine
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specimen

The role of genetic factors in ependymoma susceptibility

Lead Researcher
Maral Adel Fahmideh, PhD
Lead Institution
Baylor College of Medicine
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specimen

Circular RNAs in Medulloblastoma

Lead Researcher
Peter George Zaphiropoulos, PhD
Lead Institution
Karolinska Institutet
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specimen

BGI Validation Cohort

Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Choroid Plexus Tumor (CPT) therapies based on patient derived cell culture resources

Lead Researcher
Mark Souweidane, MD
Lead Institution
Weill Cornell Medicine
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specimen

Integrative functional genomics of recurrent childhood medulloblastoma.

Lead Researcher
Javad Nazarian, PhD
Lead Institution
Children’s National Hospital
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specimen

Integrated Genomic Analysis to elucidate the role of PIKC3A and 10q LOH as Unique drivers and cooperating events in pediatric high grade gliomas

Lead Researcher
Ian Pollack, MD
Lead Institution
UPMC Children’s Hospital of Pittsburgh
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specimen

HTG EdgeSeq system evaluation using CBTTC FFPE research specimens.

Lead Researcher
Mateusz Koptyra, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Sequencing of CBTTC Biorepository

Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Epigenetic basis of gender differences in pediatric GBM

Lead Researcher
Sheng Li, PhD
Lead Institution
Weill Cornell Medicine
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specimen

Medulloblastoma High Resolution Genomic Data for the CBTTC Repository

Lead Researcher
Tom Curran
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Genomic evaluation of malignant pediatric cortical tumors

Lead Researcher
Sarah Leary, MD
Lead Institution
Seattle Children’s Hospital
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specimen

GPC2 CAR T immunotherapy against pediatric central nervous system tumors

Lead Researcher
Jessica Foster, MD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Identification and functional targeting of alternative splice site usage in pediatric high-grade gliomas

Lead Researcher
Jo Lynne Rokita, PhD
Lead Institution
Children’s National Hospital
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specimen

Multi-modal data integration and functional screening to discover druggable targets in pediatric low-grade glioma

Lead Researcher
Pedro Costa-Pinheiro
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Exploration of IDO1 as a therapeutic target in pediatric central nervous system tumors

Lead Researcher
Rishi Lulla, MD, MS
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
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specimen

Neurocytoma WGS and RNAseq

Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Target identification and modeling of NF1-associated low-grade glioma

Lead Researcher
Michael Fisher, MD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Targeting Replicative Stress in Pediatric Brain Tumors with ALT

Lead Researcher
Kristina Cole, MD, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Proteogenomic Identification of Structural Variations

Lead Researcher
Brian Rood, MD
Lead Institution
Children’s National Hospital
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specimen

Comprehensive molecular analysis of pediatric thalamic tumors

Lead Researcher
Javad Nazarian, PhD
Lead Institution
Children’s National Hospital
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specimen

Development of the ganglioside GD2 as a biomarker and clinical trial endpoint for childhood cancers

Lead Researcher
Frank Balis, MD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Identifying tumor cell vulnerabilities in recurrent/progressive human medulloblastomas by single-cell RNA-seq

Lead Researcher
Ninib Baryawno, PhD
Lead Institution
Karolinska Institutet
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specimen

Evaluating the Efficacy of ZIKV Oncolytic Virus Killing Efficiency on Tumor Cell Lines

Lead Researcher
Youssef Kousa, MS, DO, PhD
Lead Institution
Children’s National Hospital
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specimen

Characterizing ATRT subtype evolution

Lead Researcher
Jo Lynne Rokita, PhD
Lead Institution
Children’s National Hospital
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specimen

Differentiation Induction effects of thyroid hormone on tumor cells from atypical teratoid rhabdoid tumor and diffuse midline gliomas

Lead Researcher
Zeng-Jie Yang, MD, PhD
Lead Institution
Fox Chase Cancer Center
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specimen

Development of neoantigen mRNA vaccines for pediatric brain tumors

Lead Researcher
Jessica Foster, MD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Examine GFAP-expressing tumor cells

Lead Researcher
Yanxin Pei
Lead Institution
Children’s National Hospital
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specimen

Secretion of GD2-CD3 BiTEs from B7H3 CAR T-Cells Enhances their Anti-Tumor Activity in Pediatric High-Grade Gliomas

Lead Researcher
Shahab Asgharzadeh, MD
Lead Institution
Children's Hospital Los Angeles
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specimen

Antibody-Drug Conjugate for Pediatric Gliomas

Lead Researcher
Neel Pasricha
Lead Institution
"University of California, San Francisco "
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specimen

Development of Blood Plasma cfDNA Assay to Detect the Alternative Lengthening of Telomeres (ALT) Phenotype in Pediatric High-Grade Glioma Patients

Lead Researcher
C. Patrick Reynolds, MD, PhD
Lead Institution
Texas Tech University Health Science Center School of Medicine
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specimen

Role of CRK and CRKL in tumor cell migration in pediatric high grade glioma cell lines

Lead Researcher
Taeju Park, PhD
Lead Institution
Children's Mercy Kansas City
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specimen

Developing a Local Delivery System for Group 3 Medulloblastoma

Lead Researcher
Betty Tyler
Lead Institution
Johns Hopkins University
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specimen

New Treatments for Pediatric Brain Tumors

Lead Researcher
Miriam Bornhorst, MD
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
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specimen

Validation of tumor splice targets

Lead Researcher
Jo Lynne Rokita, PhD
Lead Institution
Children’s National Hospital
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specimen

Assessing glioma gene expression signatures from patient biofluids

Lead Researcher
John Prensner, MD, PhD
Lead Institution
University of Michigan
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specimen

Overcoming immunotherapy resistance in Group 3 medulloblastoma

Lead Researcher
Jiyang Yu, PhD
Lead Institution
St. Jude Children's Research Hospital
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specimen

Evaluating inhibitors of exosomes secretion as pan-treatment for medulloblastoma

Lead Researcher
Marina Sokolsky, PhD
Lead Institution
UNC Chapel Hill
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specimen

Epitranscriptomic characterization of pediatric central nervous system tumors

Lead Researcher
Monica Pomaville, MD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Neurosurgically-applied chemotherapy for childhood brain tumours arising in the posterior fossa using a biodegradable paste

Lead Researcher
Ruman Rahman, PhD
Lead Institution
University of Nottingham
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specimen

Predictive biomarkers of cognitive outcome in children who received radiation therapy

Lead Researcher
Sabine Mueller
Lead Institution
UCSF Benioff Children’s Hospital
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specimen

Molecular and Functional Characterization of Paediatric Solid Tumours

Lead Researcher
Ron Firestein, MD, PhD
Lead Institution
Hudson Institute of Medical Research
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specimen

Targeting neurodevelopmental pathways in pediatric high-grade gliomas

Lead Researcher
Manuel Valiente, DVM / PhD
Lead Institution
Spanish National Cancer Research Centre
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specimen

Proteogenomic characterization of pediatric hematopoietic malignancies

Lead Researcher
Richard Aplenc, MD, PhD, MSCE
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Validation of Germline Variants

Lead Researcher
Sharon Diskin, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Metabolic and proteomic landscapes of DMG and DHG: Navigating uncharted paths for therapeutic discovery

Lead Researcher
Cynthia Hawkins, MD, PhD
Lead Institution
The Hospital of Sick Children (Sick Kids)
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specimen

Identification of hCMV antigens in pediatric brain tumors

Lead Researcher
Eric Thompson, MD
Lead Institution
University of Chicago
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data

Mechanism of action and efficacy of ONC201 and ONC206 in DMG preclinical models

Lead Researcher
Varun Vijay Prabhu, BPharm, MS, PhD
Lead Institution
Chimerix
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Generation of a Tissue Micro Array (TMA) from pediatric brain tumor patients

Lead Researcher
Javad Nazarian, PhD
Lead Institution
Children’s National Hospital
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specimen

T cell Receptor Therapies for pediatric High-Grade Gliomas

Lead Researcher
Anthony Wang, MD
Lead Institution
Ronald Regan UCLA Medical Center
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specimen

Drug development for pediatric HGG

Lead Researcher
Michalina Janiszewska, PhD
Lead Institution
The Wertheim UF Scripps Institute
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specimen

Understanding molecular and cellular mechanisms and identifying drug targets in human cancers

Lead Researcher
Rasika Samarasinghe, PhD
Lead Institution
Deakin University
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specimen

Targeting Cell Surface ALK

Lead Researcher
Yael Mosse, MD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Investigating somatic mutations in the normal tissues of neurofibromatosis type 1

Lead Researcher
Sam Behjati, BA, BMBCh, PhD, MRCPCH
Lead Institution
Wellcome Sanger Institute
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specimen

Proteomics X01

Lead Researcher
Brian Rood, MD
Lead Institution
Children’s National Hospital
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specimen

Establishment of Liquid Biopsy Platforms from longitudinal medulloblastoma patients

Lead Researcher
Javad Nazarian, PhD
Lead Institution
Children’s National Hospital
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specimen

Evaluating immune biomarkers overlapping in tumor and CSF in pediatric brain tumors

Lead Researcher
Robyn Gartrell, MD, MS
Lead Institution
Columbia University
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specimen

Novel organoid model generation for transformed gliomas in patients with NF1

Lead Researcher
Javad Nazarian, PhD
Lead Institution
Children’s National Hospital
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specimen

CD47 Checkpoint Blockade to treat Choroid Plexus Carcinoma

Lead Researcher
Samuel Cheshier, M.D.,Ph.D.
Lead Institution
Huntsman Cancer Institute
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specimen

Striking brain tumor metabolic vulnerabilities through identification of synthetic lethal pairs

Lead Researcher
Elena Mariotto, PhD
Lead Institution
"University of Padova, Italy"
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specimen

Analyzing circulating tumor DNA in childhood ependymoma CSF

Lead Researcher
Amy A Smith, MD
Lead Institution
Orlando Health Arnold Palmer Hospital for Children
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specimen

Tumor Chemo-Sensitivity Assays for therapy and Targeting Cancer Stem-Like Cell in Patients Affected by high grade glioma

Lead Researcher
Anna Maria Buccoliero M.D, PhD
Lead Institution
Meyer Children’s Hospital
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specimen

Targeting Glioma Oncoproteins with Peptide Centric CAR T Cells

Lead Researcher
Thomas De Raedt, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Proteomic Analysis of Pediatric Craniopharyngiomas

Lead Researcher
Brian Rood, MD
Lead Institution
Children’s National Hospital
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specimen

Identification of Novel therapeutics for choroid plexus carcinoma

Lead Researcher
Mark Souweidane, MD
Lead Institution
Weill Cornell Medicine
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specimen

High-trhoughput drug screening of adamantinomatous craniopharyngioma primary cell lines

Lead Researcher
Jeffrey Greenfield, MD, PhD
Lead Institution
Weill Cornell Medicine
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specimen

Identifying Neuro-Glycoproteome Disruption in Congenital Disorders of Glycosylation

Lead Researcher
Andrew Edmondson, MD, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Pediatric Brain Tumor Classification Using Transcriptional Profiles from Low-Cost Nanopore mRNA Sequencing

Lead Researcher
David Kram, MD, MCR
Lead Institution
Wake Forest Baptist Health
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specimen

Assessing Activity of Agents Targeting ALT Cancers in Pediatric Brain Tumor Cell Lines

Lead Researcher
Charles Patrick Reynolds, MD, PhD
Lead Institution
Texas Tech University Health Science Center School of Medicine
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specimen

Mitochondria and Cancer Connections

Lead Researcher
Marni Falk, MD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Lipid nanoparticles for the treatment of neurofibromatosis type 2

Lead Researcher
Michael Mitchell, PhD
Lead Institution
University of Pennsylvania
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specimen

Novel Polyvinyl-alcohol microsphere for Everolimus delivery for Subependymal Giant Cell Astrocytoma

Lead Researcher
Lynn Louis, PhD
Lead Institution
Technological University of the Shannon
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specimen

Role of the Immunosuppressive Tumor Microenvironment in Therapeutic Resistance in Pediatric CNS Cancers

Lead Researcher
Kavitha Yaddanapudi, PhD
Lead Institution
University of Louisville School of Medicine
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specimen

CBTN PBTA X01 Data Generation Project

Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Profiling the amino acid transporter landscape to inform fluorescent dye development for improved surgical outcome of image-guided intervention in adolescent and young adult glioma patients

Lead Researcher
Stefan Harmsen, PhD
Lead Institution
University of Pennsylvania
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specimen

Drivers of recurrence in PFA ependymoma

Lead Researcher
Vijay Ramaswamy, MD, PhD, FRCPC
Lead Institution
The Hospital of Sick Children (Sick Kids)
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specimen

The role of non-coding RNA in development of pediatric brain tumors

Lead Researcher
Ruty Shai, PhD
Lead Institution
Sheba Medical Center
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specimen

Pharmaco-proteogenomic profiling of pediatric high-grade gliomas

Lead Researcher
Matthew Dun, PhD
Lead Institution
University of New Castle
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specimen

Optical Genome Mapping for the discover of novel structural variants in pediatric brain tumors

Lead Researcher
Miriam Bornhorst, MD
Lead Institution
Children’s National Hospital
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specimen

Establishing a thalamic glioma model

Lead Researcher
Mark Souweidane, MD
Lead Institution
Weill Cornell Medicine
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specimen

Novel platforms for developing therapies for transformed gliomas in patients with NF1

Lead Researcher
Javad Nazarian, PhD
Lead Institution
Children’s National Hospital
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specimen

Evaluating NF2 and Other Tumor Disease Mechanisms

Lead Researcher
Kathrin Meyer, PhD
Lead Institution
Nationwide Children's Hospital
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specimen

Development of CAR-T Cell Therapy for Atypical Teratoid/Rhabdoid Tumors

Lead Researcher
Peter Madsen, MD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

CBTN and Count Me In, Pediatric Brain Tumor Molecular Characterization Initiative for retrospective subjects enrolled in CBTN

Lead Researcher
Diane Diehl, PhD
Lead Institution
Broad Institute
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specimen

Characterizing the blood brain pediatric brain tumors

Lead Researcher
Mark Souweidane, MD
Lead Institution
Weill Cornell Medicine
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data

Project Hope, High-Grade Glioma-Omics in Pediatric and AYA

Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Clinical and molecular characterization of rare and newly defined brain tumor entities Including CNS sarcomas, BCOR altered tumors, astroblastomas/MN-1 altered tumors. PLAG1 altered tumors and histologically ambiguous/unclassifiable brain tumors

Lead Researcher
Adriana Fonseca, MD
Lead Institution
Children’s National Hospital
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data

Development of Cancer Immunoprevention in a High-Risk Population of CMMRD: Characterization of Frameshift Neoantigens in Mismatch Repair Deficient Individuals

Lead Researcher
Yurong Song, PhD
Lead Institution
Frederick National Laboratory for Cancer Research
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data

Advancing DMG Drug Discovery with an Organoid-Based Toolkit

Lead Researcher
Zhaohui Wang, PhD
Lead Institution
Terasaki Institute for Biomedical Innovation
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data

Profiling non-canonical open reading frames in pediatric brain cancer

Lead Researcher
John Prensner, MD, PhD
Lead Institution
University of Michigan
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data

The Role of Histone Chaperones in H3.3K27M-altered Pediatric Diffuse Midline Glioma

Lead Researcher
Angela Liou, MD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

EXPRESSION OF EAAT2 IN DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMORS (DNT) AND IN ANGIOCENTRIC GLIOMA. ITS POSSIBLE ROLE IN THE PATHOGENESIS OF THE EPILEPSY

Lead Researcher
Anna Maria Buccoliero M.D, PhD
Lead Institution
Meyer Children’s Hospital
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specimen

Methylation Profiling of Pediatric Brain Tumors

Lead Researcher
Brian Rood, MD
Lead Institution
Children’s National Hospital
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data

iPC EU Horizon 2020 – Individualized Paediatric Cure: Cloud-based virtual-patient models for precision paediatric oncology

Lead Researcher
Dejan Stepec, MS
Lead Institution
XLAB d.o.o.
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specimen

Use of ependymoma cell lines to test for new therapeutic vulnerabilities

Lead Researcher
Marcel Kool, PhD
Lead Institution
Hopp Children's Cancer Center Heidelberg
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specimen

Oncogene-Induced Senescence in RTK-fused Infant High Grade Gliomas

Lead Researcher
David Kram, MD, MCR
Lead Institution
Wake Forest Baptist Health
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specimen

Investigating the tumorigenesis mechanisms and vulnerabilities of pediatric high-grade gliomas with H3G34R/V

Lead Researcher
Yang Shi, PhD
Lead Institution
Boston Children's Hospital/Ludwig Institute for Cancer Research-University of Oxford
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specimen

MET alterations in DMGs

Lead Researcher
Payal Jain, PhD
Lead Institution
Children’s Hospital of Philadelphia
Details
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specimen

Elucidating Heterogeneity of Resistance Across Molecular Subgroups of Pediatric Ependymomas to Inform Future Therapeutics

Lead Researcher
Jeffrey Greenfield, MD, PhD
Lead Institution
Weill Cornell Medicine
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specimen

RP58 and SMARCB1 in AT/RT pathogenesis

Lead Researcher
Nadia Dahmane, PhD
Lead Institution
Weill Cornell Medicine
Details
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specimen

Evaluation of drug vulnerability of NF2 tumor models

Lead Researcher
Joseph Kissil, PhD
Lead Institution
The Wertheim UF Scripps Institute
Details
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specimen

Pre-clinical Studies for NF2 Schwannomas

Lead Researcher
Cristina Fernandez-Valle, PhD
Lead Institution
University of Central Florida
Details
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specimen

Elucidating the ETMR Microenvironment using Next Generation Imaging and Multi-omics Technologies

Lead Researcher
Claire Carter, PhD
Lead Institution
Hackensack Meridian Health Network
Details
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data

From Data to Treatment: AI-Driven Identification of Molecular Targets and Bio-Inspired Therapeutics for Pediatric Glioma

Lead Researcher
Coralie Ebert
Lead Institution
MeNow Ltd
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data

Bayer NTRK Fusion Project

Lead Researcher
Rohan Pathmanathan
Lead Institution
Bayer Aktiengesellschaft
Details
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data

Analysis of outcomes in recently treated subjects with DIPG

Lead Researcher
Joan Robbins, PhD
Lead Institution
DNAtrix
Details
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data

Multi-Tensor Decompositions for Personalized Pediatric Glioma Diagnostics and Prognostics

Lead Researcher
Sri Priya Ponnapalli, PhD
Lead Institution
"Eigengene, Inc"
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data

Integrative analysis of childhood cancers

Lead Researcher
Charles Vaske, PhD
Lead Institution
NantOmics
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data

Determining Prognostic Factors and Genetic Markers that Impact Survival in Recurrent Pediatric Medulloblastoma

Lead Researcher
Chetan Betagowda, MD, PhD
Lead Institution
Johns Hopkins Medicine
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data

Sex-specific gene expression signatures in pediatric brain tumors

Lead Researcher
Josh Rubin, M.D., Ph.D.
Lead Institution
Washington University School of Medicine
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data

Genetic architecture of molecular phenotypes in pediatric brain cancers

Lead Researcher
Sebastian Waszak, PhD
Lead Institution
UCSF Benioff Children’s Hospital
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data

Artificial Intelligence for Pediatric Brain Tumor Detection and Prediction of Disease Progression

Lead Researcher
Patrick Hales, PhD
Lead Institution
University College London
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data

Investigating the immune response in pediatric glioma subsets

Lead Researcher
Joanna Phillips, MD, PhD
Lead Institution
UCSF Benioff Children’s Hospital
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data

Detecting driver mutations of central nervous system germ cell tumors

Lead Researcher
Jiguang Wang, PhD
Lead Institution
Hong Kong University of Science and Technology (HKUST)
Details
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data

Aberrant splicing candidates as potential neoantigen expression in HGG

Lead Researcher
Patrick Pirrotte, PhD
Lead Institution
The Translational Genomics Research Institute (TGen)
Details
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data

Searching for Differences in Molecular Profile of Pediatric Gliomas

Lead Researcher
Nikolay Ivanov, MD, MS
Lead Institution
Weill Cornell Medicine
Details
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data

Structural Variants in Human and Canine Cancer datasets

Lead Researcher
Charles Lee, Ph.D., D.Sc., FACMG, FRSC
Lead Institution
The Jackson Laboratory
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data

Targeting Master Regulator Dependencies in Diffuse Intrinsic Pontine Glioma (DIPG)

Lead Researcher
Jovana Pavisic, MD
Lead Institution
Memorial Sloan Kettering Cancer Center
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data

Precision Imaging of Pediatric High-grade Gliomas with Quantitative Diffusion Weighted Imaging and Texture Analysis to Identify Imaging Biomarkers That Predict Tumor Genetics and Patient Outcomes

Lead Researcher
Mariam Aboian, MD, PhD
Lead Institution
Yale University
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data

High dimensional protein characterization of tumor tissues and relevance to outcomes in immunotherapy clinical trials

Lead Researcher
Kristina Cole, MD, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Defining the role of the histone 3 (H3.3G34R) mutation in the pathogenesis of pediatric high grade astrocytoma

Lead Researcher
Cynthia Hawkins, MD, PhD
Lead Institution
The Hospital of Sick Children (Sick Kids)
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data

Proteomic Analysis of CBTTC Cell Lines (Procan)

Lead Researcher
Roger Reddel, MD, BSc (Med), MBBS, FRACP, FAAHMS, FAA
Lead Institution
Children's Medical Research Institute
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data

Defining Molecular Neighborhoods for Pediatric HGG

Lead Researcher
Kenneth Cohen, MD, MBA
Lead Institution
Johns Hopkins All Children’s Hospital
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data

Stand Up 2 Cancer

Lead Researcher
Mi-Youn Brusniak PhD, PMP
Lead Institution
Fred Hutchinson Cancer Research Center
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data

Comparison of fusion calling platforms in pediatric DIPG and high‐grade glioma

Lead Researcher
Carl Koschmann, MD
Lead Institution
University of Michigan
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data

Developing Summative Measures of Paediatric Cancer Risk

Lead Researcher
Mark Cowley, BSc, PhD
Lead Institution
"Children's Cancer Institute (Sydney, AU)"
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data

Novel neoantigen detection from complex transcriptomic structures in pediatric Brain Tumors

Lead Researcher
Tamer Ahmed Mansour, MD, PhD
Lead Institution
"University of California, Davis"
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data

Mitochondrial mutations in pediatric brain cancer

Lead Researcher
Paul Boutros, Ph.D., M.B.A
Lead Institution
"University of California, Los Angeles"
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data

Splicing analysis in ependymoma

Lead Researcher
Marcel Kool, PhD
Lead Institution
Hopp Children's Cancer Center Heidelberg
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data

The Role of Mutational Signatures in the Development of Childhood Cancer

Lead Researcher
Michael Scheurer, PhD, MPH, FACE
Lead Institution
Baylor College of Medicine
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data

Exploring the somatic landscape of adult and paediatric chordoma

Lead Researcher
Adrienne Flanagan, PhD, FRCPath, BCh, BAO, LRCPI, LRCSI, FMed Sci
Lead Institution
University College London
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data

Mechanistic Modeling of high-grade glioma

Lead Researcher
Christoph Wierling, PhD
Lead Institution
Alacris Theranostics GmbH
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data

Cross-species omics integration to identify oncogenic events in pediatric brain tumors

Lead Researcher
Junmin Peng, PhD
Lead Institution
St. Jude Children's Research Hospital
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data

BRAIN MATCH

Lead Researcher
Stefan Pfister, MD
Lead Institution
"DKFZ, KiTZ (Hopp-Children's Cancer Center, Heidelberg, Germany)"
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data

Pediatric Pan-Cancer Analysis of Structural Variants

Lead Researcher
Lukas Chavez, PhD
Lead Institution
"University of California, San Diego"
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data

Genetic Variability Across Major Histocompatibility Complex

Lead Researcher
Tristan J Hayeck, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

A study of outcomes in patients with CNS tumors with BCOR mutations

Lead Researcher
Scott Raskin, DO
Lead Institution
Children’s National Hospital
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data

A highly usable and fully comprehensive proteogenomic method leveraging the breadth of genetic variation for oncogenic and//or therapeutic novel protein discovery

Lead Researcher
Alex Kentsis, MD PhD
Lead Institution
Memorial Sloan Kettering Cancer Center
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data

NF HACKATHON

Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Cross disease variant lookup in CBTTC

Lead Researcher
Yiran Guo, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Gene expression correlates of High grade versus low grade Glioma

Lead Researcher
Chad Creighton, PhD
Lead Institution
Baylor College of Medicine
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data

Landscape of tumor-infiltrating T cell repertoire of pediatric brain tumors

Lead Researcher
Gary Kohanbash, PhD
Lead Institution
UPMC Children’s Hospital of Pittsburgh
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data

Descriptive “pharmacogenomics analysis” of the CBTTC PBTA cohort

Lead Researcher
Angela Waanders, MD
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
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data

CLINICAL, RADIOLOGIC, AND MOLECULAR CHARACTERISTICS OF ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMAS

Lead Researcher
Alberto Bronisco, MD, MS
Lead Institution
UPMC Children’s Hospital of Pittsburgh
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data

CENTRAL NERVOUS SYSTEM CANCERS IN PATIENTS WITH NON-NEUROFIBROMATOSIS TYPE 1 RASopathies

Lead Researcher
Alberto Bronisco, MD, MS
Lead Institution
UPMC Children’s Hospital of Pittsburgh
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data

Body Mass Index Trajectories in Craniopharyngioma

Lead Researcher
Shana McCormack, MD, MTR
Lead Institution
Children’s Hospital of Philadelphia
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data

PNOC and SJCRH Collaborative DIPG Radiogenomic Investigation

Lead Researcher
John Lucas, MD, MS
Lead Institution
St. Jude Children's Research Hospital
Details
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data

Cancer Stemness of Pediatric Tumors

Lead Researcher
Maciej Wiznerowicz, MD, PhD
Lead Institution
International Institute for Molecular Oncology
Details
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data

Targeting Immunosuppressive Macrophage in Pediatric Brain Tumors

Lead Researcher
Erin Crotty, MD
Lead Institution
Seattle Children’s Hospital
Details
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data

Detecting Gene Fusions and Subtype Discovery in Pediatric Solid Tumors RNA-Seq using CICERO

Lead Researcher
Scott Newman, PhD
Lead Institution
St. Jude Children's Research Hospital
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data

Genomics of radiation-induced cavernomas in pediatric tumor patients

Lead Researcher
YouRong Sophie Su MD, DO
Lead Institution
University of Pennsylvania
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data

Multi-scale model of children with brain tumors

Lead Researcher
Olivier Gevaert, PhD
Lead Institution
Stanford University
Details
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data

The Australian Bioinformatics Commons Paediatric Cancer Pathfinder Project

Lead Researcher
Mark Cowley, BSc, PhD
Lead Institution
"Children's Cancer Institute (Sydney, AU)"
Details
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data

Decoding the Dark Matter of the High-Risk Paediatric Cancer Genome

Lead Researcher
Mark Cowley, BSc, PhD
Lead Institution
"Children's Cancer Institute (Sydney, AU)"
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data

Comparison of CBTTC patient data with molecularly defined stem cell models of pediatric brain tumors

Lead Researcher
Fredrik Swartling, PhD
Lead Institution
"Uppsala University, SWEDEN"
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data

Discover new therapeutics for DIPG using a systems-based approach:

Lead Researcher
Bin Chen, PhD
Lead Institution
Michigan State University
Details
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data

Germline determinants of pediatric brain tumors

Lead Researcher
Sorana Morrissy, PhD
Lead Institution
University of Calgary
Details
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data

Alternative splicing in CBTTC data

Lead Researcher
Shihao Shen, PhD
Lead Institution
Children’s Hospital of Philadelphia
Details
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data

Heath Disparities of Pediatric Brain Tumors

Lead Researcher
Xiao-Nan Li, MD, PhD
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
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data

Long non-coding RNA signature of medulloblastoma and AT/RT subtypes

Lead Researcher
Ranjan Perera, PhD
Lead Institution
Johns Hopkins Medicine
Details
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data

Germline variants in pediatric glioblastoma

Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Deciphering the molecular characteristics of pediatric meningiomas

Lead Researcher
Nadia Dahmane, PhD
Lead Institution
Weill Cornell Medicine
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data

Genomic correlates with radiation injury

Lead Researcher
Oren Becher, MD
Lead Institution
Northwestern University
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data

Predictive models for transcriptome variations

Lead Researcher
Yoseph Barash, PhD
Lead Institution
University of Pennsylvania
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data

Hudson Monash Paediatric Precision Medicine Program

Lead Researcher
Ron Firestein, MD, PhD
Lead Institution
Hudson Institute of Medical Research
Details
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data

Germline mtDNA variants and somatic mtDNA mutations in Pediatric Brain Tumors

Lead Researcher
Xiaowu Gai, PhD
Lead Institution
Children's Hospital Los Angeles
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data

Pediatric Brain Tumor Classification and Segmentation using Transfer Learning from Adult Datasets

Lead Researcher
Roy Campbell, PhD
Lead Institution
University of Illinois
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data

Relationships Between Genomic, Imaging, and Histopathologic Characteristics in Pediatric Brain Tumors

Lead Researcher
Benjamin Hartley, MD
Lead Institution
Weill Cornell Medicine
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data

Comprehensive analysis of structural variants in pediatric brain tumors

Lead Researcher
Lixing Yang, MD, MSc
Lead Institution
University of Chicago
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data

Molecular characterization of choroid plexus tumors

Lead Researcher
Christian Thomas, MD
Lead Institution
Institute of Neuropathology Münster
Details
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data

Germline and Somatic Microsatellite Genotypes in Pediatric Brain Tumors

Lead Researcher
Brian Rood, MD
Lead Institution
Children’s National Hospital
Details
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data

Epigenetic drivers in Medulloblastoma

Lead Researcher
Alexandros Tzatsos, MD, PhD
Lead Institution
George Washington University
Details
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data

Epigenetic drivers in diffuse intrinsic pontine gliomas (DIPG)

Lead Researcher
Alexandros Tzatsos, MD, PhD
Lead Institution
George Washington University
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data

Evaluating the landscape of compound heterozygous variants in pediatric diseases

Lead Researcher
Stephen Piccolo, PhD
Lead Institution
Brigham Young University
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data

Children’s Brain Tumor Tissue Consortium Pediatric Brain Tumor Proteomics Pilot

Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Treehouse Childhood Cancer Initiative: Identification of therapeutic leads for individual pediatric cancer patients via pan-cancer analysis

Lead Researcher
David Haussler, PhD
Lead Institution
University of California Santa Cruz - Treehouse Childhood Cancer Initiative (UCSC)
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data

Genetic Polymorphisms and Neurocognitive Outcomes in Pediatric Brain Tumor Survivors

Lead Researcher
Angela Waanders, MD
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
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data

Identification of non-coding drivers from brain tumour genomes

Lead Researcher
Lincoln Stein, MD, PhD
Lead Institution
Ontario Institute for Cancer Research
Details
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data

Fusion Analysis in CBTTC RNAseq data

Lead Researcher
Olivier Elemento, PhD
Lead Institution
Weill Cornell Medicine
Details
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data

In silico neo-antigen detection in high grade pediatric brain tumors utilizing RNA-seq and WGS

Lead Researcher
Peter Madsen, MD
Lead Institution
Children’s Hospital of Philadelphia
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data

Derek Wainright on IDO1 expression with all the CBTTC RNA-Seq data

Lead Researcher
Derek Wainwright, PhD
Lead Institution
Northwestern University
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data

Spatial evolution and somatic mutations spectrum of Gliomatosis Cerebri

Lead Researcher
Jeffrey Greenfield, MD, PhD
Lead Institution
Weill Cornell Medicine
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data

Defining the mutational landscape of pediatric brain tumors

Lead Researcher
Sharon Diskin, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Cooperating mutations in brain tumors of patients with NF1

Lead Researcher
Thomas De Raedt, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Comparison of Clinical Targeted Next Generation Sequencing (NGS) in FFPE with whole genome sequencing (WGS) of snap frozen pediatric brain tumors

Lead Researcher
Bonnie Cole, MD
Lead Institution
Seattle Children’s Hospital
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data

Cancer Predisposition in Pediatric Brain Tumors

Lead Researcher
Suzanne McFarland, MD
Lead Institution
Children’s Hospital of Philadelphia
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data

Genomic Landscape of Mixed Glial Neuronal Tumors

Lead Researcher
Lea Surrey, MD
Lead Institution
Children’s Hospital of Philadelphia
Details
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data

Identifying New Cell Surface Targets for Immunotherapy treatment of Poor Prognosis Pediatric Brain Tumors

Lead Researcher
Misty Jenkins, PhD
Lead Institution
Walter and Eliza Hall of Medical Research
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data

Immunogenomic landscape of pediatric cancers

Lead Researcher
Trevor Pugh, PhD, FACMG
Lead Institution
University Health Network
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data

identify novel therapeutic targets and biomarkers in non-coding genome of pediatric cancers

Lead Researcher
Lihua Zou, PhD
Lead Institution
Northwestern University
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data

Characterizing the Prevalence of ETMR by Molecular Signature

Lead Researcher
Derek Hanson, MD
Lead Institution
Hackensack Meridian Health Network
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data

Detection of cooperative and mutually exclusive genetic alterations in pediatric cancer

Lead Researcher
Patrick Kemmeren, PhD
Lead Institution
Princess Máxima Center for Pediatric Oncology
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data

Classification of Pediatric Brain Tumor

Lead Researcher
Ajeya S R
Lead Institution
Vidyavardhaka College Of Engineering
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data

Characterizing Tumor Diffusion in Gliomatosis Cerebri Using Radiology and MRI Data

Lead Researcher
Sabine Mueller, MD, PhD
Lead Institution
UCSF Benioff Children’s Hospital
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data

Long read sequencing for rapid diagnosis of pediatric brain tumors

Lead Researcher
Derek Wong
Lead Institution
Children’s Hospital of Philadelphia
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data

HD-GLIO 2.0

Lead Researcher
Gianluca Brugnara
Lead Institution
Bonn University Hospital (Universitätsklinikum Bonn)
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data

Image-Based Classification of Pediatric Posterior Fossa Tumors: An End-to-End Solution

Lead Researcher
Asim Bag
Lead Institution
St. Jude Children's Research Hospital
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data

Clinical Outcomes Following Volumetric Analysis of Extent of Resection in Medulloblastoma

Lead Researcher
Peter Madsen, MD
Lead Institution
Children’s Hospital of Philadelphia
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data

Molecular Predictors of e-Radiation Resistance in H3K27M alerted diffuse midline gliomas

Lead Researcher
Sabine Mueller, MD, PhD
Lead Institution
UCSF Benioff Children’s Hospital
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data

Automated Segmentation and Radiomics Integration for Non-Invasive Genetic and Prognostic Prediction in Pediatric High-Grade Gliomas

Lead Researcher
Kartik Reddy
Lead Institution
Children’s Healthcare of Atlanta
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data

Identification of medulloblastoma metastases

Lead Researcher
Eric Thompson
Lead Institution
Washington University School of Medicine
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data

Understanding the role of glioma-associated oligodendroglia in glioma progression

Lead Researcher
Claudia K Petritsch
Lead Institution
Stanford University
Details
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data

FOXR2 driver events and clinical outcomes in CNS neuroblastoma with FOXR2 activation

Lead Researcher
Jessica Tsai
Lead Institution
Children's Hospital Los Angeles
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data

Characterizing the landscape of cancer-specific splicing aberrations across pediatric tumors

Lead Researcher
Darwin Kwok
Lead Institution
UCSF Benioff Children’s Hospital
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data

Artificial Intelligence Meets Medulloblastoma: Breaking Barriers in Subgroup Prediction

Lead Researcher
Maysa Al-husseini
Lead Institution
King Hussein Cancer Center
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data

Quantitative analysis of radiographic images and its application to automated diagnosis to improve healthcare efficiency

Lead Researcher
Akifumi Hagiwara
Lead Institution
Juntendo University
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data

Multiparametric Magnetic Resonance Imaging and Machine Learning-Based Predicts Prognosis and Treatment Response in Pediatric Medulloblastoma

Lead Researcher
Lujiao Chen
Lead Institution
"Shaoxing People’s Hospital, Shaoxing, Zhejiang Province, China;"
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data

Brain tumor prediction using lstm and rnn

Lead Researcher
Rishabh Dubey
Lead Institution
University of Iowa
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data

Using AI for Diagnostic and Prognostic Prediction in Paediatric Brain Cancer

Lead Researcher
Jordan Hansford
Lead Institution
University of Adelaide; Australian Institute of Machine Learning
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data

Radiogenomics and survival correlation of MRI based biomarker using deep learning

Lead Researcher
Akshaykumar Kamble
Lead Institution
Deep Learning Institute of Radiological Sciences
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data

Analysis of chromatin pathways as regulators of high grade glioma gene expression patterns

Lead Researcher
Jamie Anastas, PhD
Lead Institution
Boston Children's Hospital
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data

Personalized Survival Prediction of Glioma via Multi-modal Data

Lead Researcher
Jieqiong Wang
Lead Institution
University of Nebraska Medical Center
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data

Brain Age as a Biomarker for Survivorship Outcomes in Pediatric Brain Tumor Patients: A Neuroimaging-Based Investigation

Lead Researcher
Sahil Bajaj
Lead Institution
UT MD Anderson Cancer Center
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data

Radiologic-Molecular Correlation in DMG Recurrence

Lead Researcher
Miriam Bornhorst, MD
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
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data

circRNA atlas of pediatric brain tumors

Lead Researcher
Marc Remke
Lead Institution
Universitäts des Saarlandes
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data

The role of “adult onset” cancer predisposition genes in pediatric cancer

Lead Researcher
Miriam Bornhorst, MD
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
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data

Design, implementation, and validation of novel multimodal deep learning algorithms for clinical translation of diagnostic and prognostic tools for pediatric brain tumors

Lead Researcher
Farzad Khalvati
Lead Institution
The Hospital of Sick Children (Sick Kids)
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data

Assessing the importance of reoperation in overall survival in pediatric malignant brain tumors

Lead Researcher
Eric Thompson
Lead Institution
Washington University School of Medicine
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data

Automated Classification of Pediatric Posterior Fossa Tumors Using Machine Learning and Deep Learning on MRI Data

Lead Researcher
Marianne Schell
Lead Institution
Heidelberg University Hospital
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data

Integrative Multi-omics Approaches to identify novel biomarker-informed therapeutic targets for childhood cancer.

Lead Researcher
Claire Sun
Lead Institution
Hudson Institute of Medical Research
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data

Digitizing Pathology: Enhancing Tumor Diagnosis with AI and Whole Slide Imaging

Lead Researcher
Jennifer Cotter
Lead Institution
Children's Hospital Los Angeles
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data

Deep Learning Based Interpretable Pediatric Brain Tumors Segmentation and Classification

Lead Researcher
Ayse Keles
Lead Institution
"University of Galway, School of Computer Science"
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data

Advancing radiomic tools for brain tumours: Enriching data sets and developing novel AI approaches

Lead Researcher
John Apps
Lead Institution
University of Birmingham
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data

Role of CRK and CRKL in high grade glioma cell migration

Lead Researcher
Taeju Park, PhD
Lead Institution
Children's Mercy Kansas City
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data

HG34-mutant gliomas

Lead Researcher
Chetan Betagowda, MD, PhD
Lead Institution
Johns Hopkins Medicine
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data

Automated Multimodal Data Integration and Analysis for Pediatric Brain Tumor Imaging and Pathology

Lead Researcher
Ariana Familiar, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

lncRNA Regulation of Chromatin Remodeling in Pediatric Brain Tumors

Lead Researcher
Hua-Sheng Chiu
Lead Institution
Texas Children’s Hospital
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data

AI/ML derivation and experimental validation of ATRT biomarkers of survival and response to treatment

Lead Researcher
Jessica Tsai
Lead Institution
Children's Hospital Los Angeles
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data

Evolutionary trajectories of pediatric cancers

Lead Researcher
Giulio Caravagna
Lead Institution
Università degli studi di Trieste
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data

Prediction of radiotherapy benefit using genomic-adjusted radiation dose in pediatric low grade gliomas and ependymomas

Lead Researcher
Javier Torres-Roca
Lead Institution
Moffitt Cancer Center
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data

Advancing Pediatric Cancer Diagnosis: Unveiling ecDNA Patterns in FFPE Tissue Images Using Machine Learning

Lead Researcher
Zahra Ahmadi
Lead Institution
Medizinische Hochschule Hannover
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data

Hypoxia and Immune Infiltration in Medulloblastoma

Lead Researcher
Hideho Okada
Lead Institution
UCSF Benioff Children’s Hospital
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data

DMG genomic signatures as predictors of radiation response

Lead Researcher
Cassie Klein, MD, MAS
Lead Institution
UCSF Benioff Children’s Hospital
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data

Understanding a rare familial cancer syndrome associated with multifocal malignant peripheral nerve sheath tumors

Lead Researcher
David Thomas
Lead Institution
University of New South Wales
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data

None Provided

Lead Researcher
Marco Gallo, PhD
Lead Institution
Texas Children’s Hospital
Details
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data

No Change

Lead Researcher
Marco Gallo, PhD
Lead Institution
University of Calgary
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data

Germline mutations in pediatric brain tumors

Lead Researcher
Marco Gallo, PhD
Lead Institution
Texas Children’s Hospital
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data

An integrated deep learning model to accurately predicts DNA methylation signatures and tumor types from histopathology in central nervous system tumors

Lead Researcher
Lalchung Nunga
Lead Institution
National Cancer Institute
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data

Enhancing Clinical Data for CBTN through Automated EHR extraction

Lead Researcher
Allison Heath, PhD, MS, BS
Lead Institution
Children’s Hospital of Philadelphia
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data

Genomic and transcriptomic profiling

Lead Researcher
Javad Nazarian, PhD
Lead Institution
Children’s National Hospital
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data

Novel ADC targets in Pediatric Glioma

Lead Researcher
Florian Muller
Lead Institution
Powder Gate Discovery
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data

Genetic mutations and Epigenetic data

Lead Researcher
Javad Nazarian, PhD
Lead Institution
Children’s National Hospital
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data

Exploring Shared and Unique Mechanisms of Focal Amplification in Pediatric and Adult Brain Tumors

Lead Researcher
Hoon Kim, PhD
Lead Institution
Sungkyunkwan University School of Pharmacy
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data

Record ID 1296 Page 8 Characterization of splicing-derived neoantigens in pediatric brain tumors

Lead Researcher
Darwin Kwok
Lead Institution
UCSF Benioff Children’s Hospital
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data

Human-centered design of clinical AI to support the diagnosis of pediatric suprasellar tumors

Lead Researcher
Todd Hankinson, MD
Lead Institution
Children's Hospital Colorado/ University of Colorado Anschutz Medical Campus
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data

CAR Target discovery

Lead Researcher
Jessica Foster, MD
Lead Institution
Children’s Hospital of Philadelphia
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data

Identification of pediatric DIPG targets and Drug Discovery

Lead Researcher
Antonio Scilimati, PhD
Lead Institution
University of Bari (Italy)
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data

Developing an imaging clinical decision support tool

Lead Researcher
Angela Waanders, MD
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
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data

Federated Cancer Data – Paediatric High Grade Glioma Pathfinder Project

Lead Researcher
Angela Waanders, MD
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
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data

Genetic analysis of recurrent medulloblastoma

Lead Researcher
Hiromichi Suzuki, MD, PhD
Lead Institution
National Cancer Center (Japan)
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data

Precision Diagnosis of Pediatric Tumors Based on Artificial Intelligence Pathology Analysis

Lead Researcher
Biyue Zhu, PhD
Lead Institution
Children's Hospital of Chongqing Medical University
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data

Clinical Characteristics and Factors Influencing Outcomes of Diffuse Hemispheric Glioma, H3 G34-mutant: A Multi-Institutional Retrospective Cohort Study

Lead Researcher
Cameron Crowell, MD
Lead Institution
"IWK Health Centre, Dalhousie University"
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data

Defining the global impact of germline structural variation on the transcriptome of human pediatric brain cancers

Lead Researcher
Chad Creighton, PhD
Lead Institution
Baylor College of Medicine
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data

GDF15 in Pediatric Neuro-Oncology Patients

Lead Researcher
Daniel Runco, MD, MS
Lead Institution
Seattle Children’s Hospital
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data

Pediatric and Young Adult Meningioma

Lead Researcher
Joshua Byers, MD
Lead Institution
UCSF Benioff Children’s Hospital
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data

Analysis of allele specific copy-number profiles in the CBTN HGG HOPE cohort

Lead Researcher
Marcin Cieslik, PhD
Lead Institution
University of Michigan
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data

Neoadjuvant LAG-3 Inhibitor + PD-1 Inhibitor in Children with Recurrent or Progressive High-Grade Glioma and Ependymoma

Lead Researcher
Tom Belle Davidson, MD
Lead Institution
Children's Hospital Los Angeles
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data

Explainable AI prediction model with radiogebomics analysis

Lead Researcher
Daisuke Kawahara, PhD
Lead Institution
Hiroshima University
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data

Classification of central nervous system tumors based on predicting DNA methylation from digital pathology.

Lead Researcher
Kenneth Aldape, MD
Lead Institution
National Cancer Institute
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data

Finding genetic and imaging biomarkers of tumour subtype and clinical outcome in childhood brain cancer

Lead Researcher
Shraddha Pai, PhD
Lead Institution
Ontario Institute for Cancer Research
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data

Integrative multi-omics analysis reveals dynamic interaction between brain tumors and the immune system

Lead Researcher
Heejin Cho, PhD
Lead Institution
Kyungpook National University
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data

Molecular Basis of Pediatric Brain Tumor Morphology

Lead Researcher
Arash Nazeri, MD
Lead Institution
St. Louis Children’s Hospital
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data

The evolution of alternative splicing in pediatric brain tumor under therapy

Lead Researcher
BaoBao Geng, MS
Lead Institution
Center of Systems Medicine Chinese Academy of Medical Sciences Institute of Systems Medicine
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data

Correlating molecular profiles of pediatric glioma specimens to multiparametric analysis of MR voxels at biopsy sites

Lead Researcher
Jason G Parker
Lead Institution
Indiana University School of Medicine
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data

Deciphering RNA modifications and functional characterization of RNA modification enzymes in Medulloblastoma

Lead Researcher
Ranjan Perera, PhD
Lead Institution
Johns Hopkins Medicine
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data

Integrated Imaging and Genomic Characterization of the Immunogenicity of Pediatric Low Grade Gliomas

Lead Researcher
Adam Kraya, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Deep learning enabled medulloblastoma prognosis and biomarker discovery

Lead Researcher
Yongji Tian, MD
Lead Institution
Beijing Tiantan Hospital Neurosurgery Center
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data

Predictive Analytics in Pediatric High-Grades Gliomas

Lead Researcher
Angela Waanders, MD
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
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data

Predicting Overall Survival for DMG Tumors Based on pre and post-RT MRI

Lead Researcher
Anahita Fathi Kazerooni, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Which Pediatric High-Grade Glioma Patients Respond to Double Alkylator Chemotherapy?

Lead Researcher
Adam Green, MD
Lead Institution
University of Colorado
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data

Alternative Splicing Analysis of pHGG

Lead Researcher
Matthew Mouck
Lead Institution
Children’s Hospital of Philadelphia
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data

MHC-1 and Histon mutation

Lead Researcher
Maria Castro, PhD
Lead Institution
University of Michigan
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data

Biology of choroid plexus carcinoma

Lead Researcher
Holly Lindsay, MD, MS
Lead Institution
Texas Children’s Hospital
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data

Medulloblastoma Multi-Omics

Lead Researcher
Paul Northcott, PhD
Lead Institution
St. Jude Children's Research Hospital
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data

Deciphering the 3D genome of pediatric brain tumors

Lead Researcher
Kathrin Pollard, PhD
Lead Institution
UCSF Benioff Children’s Hospital
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data

Clinicopathologic analysis of novel IDH-wildtype cerebral and posterior fossa diffuse high-grade gliomas

Lead Researcher
MacLean Nasrallah, MD PhD
Lead Institution
University of Pennsylvania
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data

Methotrexate Outcomes in Infant Medulloblastoma and ETMR Outcomes

Lead Researcher
Rebecca Ronsley, MD, FRCPC
Lead Institution
Seattle Children’s Hospital
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data

Creating Methylation Classifier for CNS Tumors

Lead Researcher
Marilyn M. Li, MD, MS
Lead Institution
Children’s Hospital of Philadelphia
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data

An investigation into the role of novel and understudied genes in the initiation and progression of medulloblastoma

Lead Researcher
Roger Abounader, MD, PhD
Lead Institution
University of Virginia
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data

A CBTN case study utilizing network analysis

Lead Researcher
Irene Suilan Zeng, PhD
Lead Institution
"Auckland University of Technology, New Zealand"
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data

Characterize the immune microenvironment of DMG using single-cell based deconvolution approaches

Lead Researcher
Anne Rios, PhD
Lead Institution
Princess Máxima Center for Pediatric Oncology
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data

Evaluating immune biomarkers overlapping in tumor and CSF in diffuse midline glioma (DMG)

Lead Researcher
Robyn Gartrell, MD, MS
Lead Institution
Columbia University
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data

Universal Pediatric CNS Tumor Genomic Profiling

Lead Researcher
Adam Kraya, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Optimal validation of DNA-methylation based tumor purity estimation

Lead Researcher
Antonios Papanicolau-Sengos, MD
Lead Institution
National Cancer Institute
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data

OpenPBTA: An Open Pediatric Brain Tumor Atlas

Lead Researcher
Jo Lynne Rokita, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Self-attention feature pyramid network for multimodal medical image segmentation

Lead Researcher
Nico Loesch, M.Sc.
Lead Institution
University of Technology Sydney (UTS)
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data

Pediatric Brain Tumor Classification

Lead Researcher
Anushka Sharma
Lead Institution
"International Institute of Information Technology, Bhubaneswar (IIIT-BH)"
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data

The role and regulation of tumor suppressor SETD2 in pediatric high grade glioma

Lead Researcher
Angela Liou, MD
Lead Institution
Children’s Hospital of Philadelphia
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data

Spatiotemporal multi-omics analysis of childhood ependymoma

Lead Researcher
Semin Lee, PhD
Lead Institution
Ulsan National Institute of Science and Technology
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data

Exploring microbial signatures in childhood tumors

Lead Researcher
Vicky Yao, PhD
Lead Institution
Rice University
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data

Mathematical modelling of drug delivery in brain tumour using thermosensitive hydrogel

Lead Researcher
Wenbo Zhan, PhD
Lead Institution
University of Aberdeen
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data

Regulation and Function of Circular RNAs in Atypical Teratoid Rhabdoid Tumor

Lead Researcher
Rui Zhou
Lead Institution
Johns Hopkins University
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data

Posterior Fossa Deep Learning Model Validation

Lead Researcher
Maliha Imami, HBSc
Lead Institution
Johns Hopkins University
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data

Factors Associated with High Incidence of Pediatric Bran and Central Nervous System Tumors in Kentucky

Lead Researcher
Eric B Durbin, DrPH, MS
Lead Institution
University of Kentucky
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data

BRATS validation study/no public access

Lead Researcher
Anahita Fathi Kazerooni, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Validation of a transcriptomic biomarker of pediatric meningioma outcomes and radiotherapy response

Lead Researcher
David Raleigh, MD, PhD
Lead Institution
"University of California, San Francisco "
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data

Developing Deep-Learning Approaches for the Automated Segmentation of Pediatric Tumors on Multi-Modal MRI Sequences

Lead Researcher
Ramandeep Kang
Lead Institution
University of Liverpool
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data

Characterization of pediatric CNS tumors using nanopore sequencing

Lead Researcher
Jeremy Wang, PhD
Lead Institution
UNC Chapel Hill
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data

Characterizing the molecular landscape of pediatric and adult meningiomas

Lead Researcher
Damian Andres Almiron Bonnin, MD, PhD
Lead Institution
Fred Hutchinson Cancer Research Center
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data

Comparing gene expression patterns in high v low grade gliomas to understand drivers of tumor cell invasion.

Lead Researcher
Laura Prolo, MD, PhD
Lead Institution
Lucile Packard Children’s Hospital Stanford
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data

Is KIF20A overexpressed in pediatric high-grade glioma?

Lead Researcher
Morgan Schrock, PhD
Lead Institution
The Ohio State University
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data

Developing Novel Precision Medicine for Glioblastoma

Lead Researcher
Zhi Sheng, PhD
Lead Institution
Fralin Biomedical Research Institute at VTC
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data

Paediatric Brain Tumour Classification and Segmentation

Lead Researcher
Asad Shahzad
Lead Institution
Forman Christian College
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data

Genome-wide Sequencing to Identify the Genes Responsible for Enchondromatoses and Related Malignant Tumors

Lead Researcher
Nara Sobreira, MD, PhD
Lead Institution
Johns Hopkins University
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data

Optimizing radiation for ATRT: Understanding the implications of dose and volume on outcomes

Lead Researcher
Sahaja Acharya, MD
Lead Institution
Johns Hopkins Medicine
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data

Discovering new mutations in pediatric neurocancer

Lead Researcher
Cynthia Hawkins, MD, PhD
Lead Institution
The Hospital of Sick Children (Sick Kids)
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data

MRI-based tracking of cell population dynamics to design personalised adaptive treatment protocols for glioma patients

Lead Researcher
Mohammad Amin Lessan, PhD
Lead Institution
University College London
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data

Semi-automated variant curation algorithm

Lead Researcher
Kitty Lo, PhD
Lead Institution
"Children's Cancer Institute (Sydney, AU)"
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data

Methylation profiling of pediatric CNS tumors to define molecular subtype-specific signatures

Lead Researcher
Markus List, PhD
Lead Institution
Technical University of Munich
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data

Growth hormone signaling in craniopharyngioma

Lead Researcher
Cassie Klein, MD, MAS
Lead Institution
UCSF Benioff Children’s Hospital
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data

Comparison of RNA-binding protein expressions in pediatric and adult glioblatstoma

Lead Researcher
Xinzhou Zhu, PhD
Lead Institution
"Shenzhen Institute of Advanced Technology, Chinese Academy of Science"
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data

The Radiogenomics of Molecularly-defined Pediatric Brain Tumors

Lead Researcher
Samantha Pisani, MD, PhD
Lead Institution
"University of California, San Francisco "
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data

DEI Ancestry Project

Lead Researcher
Cassie Klein, MD, MAS
Lead Institution
UCSF Benioff Children’s Hospital
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data

Investigating the Role of ERV Expression in Ependymoma

Lead Researcher
Stephen Mack, PhD
Lead Institution
St. Jude Children's Research Hospital
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data

Morphological Molecular Correlation of Pediatric Brain Tumors

Lead Researcher
Murad Alturkustani, MD
Lead Institution
"King Abdulaziz University, Jeddah, Saudi Arabia"
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data

Predicting distant metastasis and chemotherapy benefit in pediatric brain cancer

Lead Researcher
Yan-Ran (Joyce) Wang, MS, PhD
Lead Institution
Stanford University
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data

3D U-Net Segmentation Network for Measurement and Characterization of Pediatric Low-Grade Gliomas

Lead Researcher
Andreas Rauschecker, MD, PhD, MSc
Lead Institution
UCSF Benioff Children’s Hospital
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data

TRK fusion primary CNS tumors

Lead Researcher
Theodore Laetsch, MD
Lead Institution
Children’s Hospital of Philadelphia
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data

Mechanistic-based DIPG precision therapy

Lead Researcher
Zeinab Mohamed Mamdouh Abdelkareem Gomaa, M.Sc
Lead Institution
Maastricht University
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data

Pediatric brain tumor image analytics using AI

Lead Researcher
Neda Haj-Hosseini, PhD
Lead Institution
Linköping University
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data

Automatic segmentation of radiosentitive brain structure in pediatric patients with CNS tumor

Lead Researcher
Marianne Aznar, PhD
Lead Institution
University of Manchester
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data

Molecular signatures underlying radiation resistance in diffuse midline gliomas

Lead Researcher
Thien Nguyen, MD
Lead Institution
"University of California, San Francisco "
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data

Synthetic trial of everolimus in recurrent pediatric LGG patients

Lead Researcher
Sabine Mueller, MD, PhD
Lead Institution
UCSF Benioff Children’s Hospital
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data

PDGFRA expression in K27M gliomas

Lead Researcher
Mariella Filbin, MD, PhD
Lead Institution
Dana-Farber Cancer Institute
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data

Using histopathology to discover genetic alterations in pediatric brain tumors

Lead Researcher
Sabine Mueller, MD, PhD
Lead Institution
UCSF Benioff Children’s Hospital
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data

Multi-institutional analysis of recurrent central nervous system germinomas

Lead Researcher
Mohamed Abdelbaki, MD
Lead Institution
Washington University School of Medicine
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data

Survival outcome of iMB treated without adjuvant craniospinal irradiation: a pooled data analysis in the molecular era

Lead Researcher
Craig Erker, MD, MS, FRCPC
Lead Institution
"IWK Health Centre, Dalhousie University"
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data

Immune receptor recombinations in childhood brain cancer

Lead Researcher
George Blanck, PhD
Lead Institution
"University of California, San Francisco "
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data

Integrative analyses of data as part of the CFDE

Lead Researcher
Kristin Ardlie, PhD
Lead Institution
Broad Institute
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data

Analyze the relationship between the expression of specific genes and the prognosis in pediatric gliomas.

Lead Researcher
Feng Wan, MD
Lead Institution
"Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology"
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Leveraging existing pediatric low-grade tumor specimens, clinical and imaging outcome data and artificial intelligence innovations to develop integrated biomarkers of response for children with low-grade glioma

Lead Researcher
Benjamin H. Kann, MD
Lead Institution
Boston Children's Hospital
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data

Identification of novel therapeutic approaches for paediatric high-grade gliomas

Lead Researcher
Massimo Squatrito, PhD
Lead Institution
Spanish National Cancer Research Centre
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data

DIPG International Prevalence of Germline Mutations (DIPG-M)

Lead Researcher
Mark Pinese, PhD
Lead Institution
"Children's Cancer Institute (Sydney, AU)"
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data

Development of a new therapy against Diffuse Intrinsic Pontine Glioma

Lead Researcher
Terrance Johns
Lead Institution
"Telethon Kids Institute, University of Western Australia"
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data

A Comparison of Hallmark Mutations in Pediatric and Adult Brain Tumors

Lead Researcher
Kevin Judy, MD
Lead Institution
Thomas Jefferson University
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data

Landscape of germline histone mutations in pediatric brain tumor patients

Lead Researcher
Javad Nazarian, PhD
Lead Institution
Children’s National Hospital
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data

Characterizing the blood-brain-barrier in pediatric brain tumors

Lead Researcher
Mark Souweidane, MD
Lead Institution
Weill Cornell Medicine
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data

Molecular Mechanisms and Functional Impact of Aberrant Splicing in Diffuse Midline Gliomas

Lead Researcher
Ammar Naqvi, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Correlating genomic features with the immune microenvironment in pediatric glioma

Lead Researcher
Robyn Gartrell, MD, MS
Lead Institution
Columbia University
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data

The landscape of pediatric RTK-driven gliomas

Lead Researcher
Ana Guerreiro Stücklin, MD, PhD
Lead Institution
University Children’s Hospital Zürich
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data

Radiogenomic Analysis of Pediatric Brain Tumors

Lead Researcher
Pallavi Tiwari, PhD
Lead Institution
Case Western Reserve University
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data

Genetic risk factors for pediatric brain tumors

Lead Researcher
Anna Dahlin, PhD
Lead Institution
Umeå University
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data

Targeting histone H3K4me3 for the treatment of pediatric gliomas

Lead Researcher
Guifa Xi, PhD
Lead Institution
Northwestern University
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data

Germline determinants of the pediatric tumor immune microenvironment

Lead Researcher
Hannah Carter, PhD
Lead Institution
"University of California, San Diego"
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data

Investigating the etiology of genomic rearrangements in human cancers

Lead Researcher
Xiaotu Ma, PhD
Lead Institution
St. Jude Children's Research Hospital
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specimen

Molecular Characterization of Pediatric Brain Tumor Subjects and Trios within the Pediatric Brain Tumor Atlas

Lead Researcher
Mateusz Koptyra, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Diversity, Equity, and Inclusion: Translation of Informed Consent Forms

Lead Researcher
Cassie Kline, MD, MAS
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Discovering Novel Epigenetic Dependencies in Pediatric High-grade Glioma

Lead Researcher
Mariella Filbin, MD, PhD
Lead Institution
Harvard Medical School
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specimen

Cell Ecosystem and Signaling Pathways of Primary and Metastatic Pediatric Posterior Fossa Ependymoma

Lead Researcher
Pablo G. Cámara, PhD, DABMGG
Lead Institution
University of Pennsylvania
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specimen

Biomarker Identification for Neurofibromatosis Type 2 Background

Lead Researcher
Andrew Mullen, PhD
Lead Institution
NF2 Biosolutions and General Metabolics, LLC
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specimen

Developing a Novel Tumor Model to Screen for New Therapies for Spinal Ependymoma

Lead Researcher
Linda M. Smith-Resar, MD
Lead Institution
Johns Hopkins Medicine
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specimen

Gene Expression Analysis Platform Evaluation for FFPE Specimen Material-Based Studies

Lead Researcher
Mateusz Koptyra
Lead Institution
Children's Hospital of Philadelphia
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specimen

Whole Genome Sequencing and RNA Sequencing of the CBTN Bank for the Pediatric Brain Tumor Atlas

Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Integrative Functional Genomics of Recurrent Childhood Medulloblastoma

Lead Researcher
Javad Nazarian, PhD, MSc
Lead Institution
Children’s National Hospital
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data

DIPG and Other Primary Pediatric Brain Tumors

Lead Researcher
Hideho Okada, MD, PhD
Lead Institution
UCSF Benioff Children’s Hospital
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data

Immunotherapeutically-targeting IDO1 in Pediatric High-grade Glioma

Lead Researcher
Derek Wainwright, PhD
Lead Institution
Northwestern University
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data

Telomere Maintenance Across Multiple Brain Tumors

Lead Researcher
Kristina A. Cole, MD, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

In Silico Neo-antigen Detection in High-grade Pediatric Brain Tumors Utilizing RNA-seq and WGS

Lead Researcher
Peter Madsen, MD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Choroid Plexus Tumor (CPT) Therapies Based on Patient-derived Cell Culture Resources

Lead Researcher
Mark Souweidane, MD
Lead Institution
Weill Cornell Medicine
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data

Fusion Analysis in CBTN RNAseq Data

Lead Researcher
Andrea Sboner, PhD
Lead Institution
Weill Cornell Medicine
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data

Genetic Polymorphisms and Neuro-Cognitive Outcomes in Pediatric Brain Tumor Survivors

Lead Researcher
Matthew Hocking, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Treehouse Childhood Cancer Initiative: Identification of Therapeutic Leads for Individual Pediatric Cancer Patients via Cancer Analysis

Lead Researcher
David Haussler, PhD
Lead Institution
UC Santa Cruz Treehouse Childhood Cancer Initiative
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data

Children’s Brain Tumor Network Pediatric Brain Tumor Proteomics Pilot

Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Comprehensive Genomic and Immune Signature Profiling of Ependymoma and Diffuse Intrinsic Pontine Glioma

Lead Researcher
Kathleen M. Schieffer, MLS
Lead Institution
Nationwide Children's Hospital
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specimen

Pediatric Brain Tumor miRNA Profiling for the Cohort of Children’s Brain Tumor Network Specimens

Lead Researcher
Mateusz Koptyra, PhD
Lead Institution
Children’s Hospital of Philadelphia
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specimen

Project Hope: High-Grade Glioma-Omics in Pediatric and AYA

Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Alternative Splicing in CBTN Data

Lead Researcher
Shihao Shen, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Discover New Therapeutics for DIPG using a Systems-Based Approach

Lead Researcher
Bin Chen, PhD
Lead Institution
Michigan State University
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data

Descriptive “Pharmacogenomics Analysis” of the CBTN PBTA Cohort

Lead Researcher
Angela Waanders, MD, MPH
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
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Comparison of CBTN Patient Data with Molecularly-Defined Stem Cell Models of Pediatric Brain Tumors

Lead Researcher
Fredrik Swartling, PhD
Lead Institution
Uppsala University, SWEDEN
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data

Landscape of Tumor-infiltrating T-Cell Repertoire of Pediatric Brain Tumors

Lead Researcher
Gary Kohanbash, PhD
Lead Institution
UPMC Children’s Hospital of Pittsburgh
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specimen

Genomic Analysis of Oligodendrogliomas Across Pediatrics, Adolescents and Adults

Lead Researcher
Adam Resnick PhD PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Defining the Global Impact of Somatic Structural Variation on the Transcriptome of Human Pediatric Brain Cancers

Lead Researcher
Chad Creighton, PhD
Lead Institution
Baylor College of Medicine
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specimen

Oncolytic Virus to Potentiate Immune-checkpoint Blockade in Immunologically Cold Pediatric Brain Tumors

Lead Researcher
Aaron Diaz, PhD
Lead Institution
UCSF Benioff Children’s Hospital
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specimen

Exploring the Possible Role of Mutations in MTOR pathway Genes in the Pathogenesis of DNET Tumors

Lead Researcher
Anna Maria Buccoliero, MD, PhD
Lead Institution
Meyer Children’s Hospital
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data

Cross-disease Variant Lookup in CBTN

Lead Researcher
Yiran Guo, PhD
Lead Institution
Children's Hospital of Philadelphia
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specimen

CBTN Cell Lines High-Throughput Drug Screening Study (NCATS)

Lead Researcher
Mateusz Koptyra, PhD
Lead Institution
Children’s Hospital of Philadelphia
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data

Comprehensive Molecular Profiling of Pediatric Meningioma

Lead Researcher
Kathleen M. Schieffer, MLS
Lead Institution
Nationwide Children's Hospital
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data

Investigating Biomarker for Treatment Respondors and Non-respondors in PDX Model Experiment

Lead Researcher
Mi-Youn Brusniak PhD, PMP
Lead Institution
Fred Hutchinson Cancer Recerch Center
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data

Comprehensive Molecular Profiling of Pediatric Diffuse Astrocytomas: Independent Validation of Proteomic Analysis

Lead Researcher
Kathleen M. Schieffer, MLS
Lead Institution
Nationwide Children's Hospital
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data

A Highly-Usable and Fully-Comprehensive Proteogenomic Method Leveraging the Breadth of Genetic Variation for Oncogenic and/or Therapeutic Novel Protein Discovery

Lead Researcher
Alex Kentsis, MD PhD
Lead Institution
Memorial Sloan-Kettering Cancer Center
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specimen

Microglial Mosaicism in BRAFV600E Glioma Development

Lead Researcher
Estibaliz Lopez-Rodrigo, MD
Lead Institution
Weill Cornell Medicine
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data

Health Disparities of Pediatric Brain Tumors

Lead Researcher
Xiao-Nan Li, MD, PhD
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
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data

Proteomic Analysis of CBTN Cell Lines

Lead Researcher
Roger Reddel, MD, BSc (Med), MBBS, FRACP, FAAHMS, FAA
Lead Institution
The University of Sydney
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Investigating Disease Mechanism In Adamantinomatous Craniopharyngioma Using New Cell Line Models

Lead Researcher
Todd Hankinson, MD
Lead Institution
Children's Hospital of Colorado
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data

Non-coding Genetic Events in Medulloblastoma and Ependymoma

Lead Researcher
Marco Gallo, PhD
Lead Institution
University of Calgary
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Aberrant Splicing Candidates as Potential Neoantigen Expression in High-grade Glioma

Lead Researcher
Patrick Pirrotte, PhD
Lead Institution
Translational Genomics Research Institute
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specimen

Functional Dependency Mapping in Paediatric Brain Cancers

Lead Researcher
Ron Firestein, MD, PhD
Lead Institution
Hudson Institute of Medical Research
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Identification of Novel Therapeutic Approaches for pHGGs

Lead Researcher
Massimo Squatrito, PhD
Lead Institution
Spanish National Cancer Research Center (CNIO)
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Leveraging Existing Pediatric Low-Grade Tumor Specimens, Clinical and Imaging Outcome Data, and Artificial Intelligence Innovations to Develop Integrated Biomarkers of Response for Children With Low-Grade Glioma

Lead Researcher
Benjamin H. Kann, MD
Lead Institution
Harvard Medical School
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Analyze the Relationship Between the Expression of Specific Genes and the Prognosis in Pediatric Gliomas

Lead Researcher
Feng Wan, MD
Lead Institution
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
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Genetic Vulnerabilities in Supratentorial and Infratentorial Pediatric High-grade Gliomas

Lead Researcher
Massimo Squatrito, PhD
Lead Institution
Spanish National Cancer Research Center (CNIO)
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Pediatric Meningiomas

Lead Researcher
Sameer Agnihotri, PhD
Lead Institution
UPMC Children’s Hospital of Pittsburgh
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Immune Receptor Recombinations in Childhood Brain

Lead Researcher
George Blanck, PhD
Lead Institution
University of South Florida
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CDC42 RHOJ Interaction Inhibitors for the Treatment of Neurofibromatosis

Lead Researcher
Anand Ganesan, MD, PhD
Lead Institution
University of California, Irvine
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Comparison of RNA-Binding Protein Expressions in Pediatric and Adult Glioblastoma

Lead Researcher
ZHU Xinzhou, PhDShenZhen Institutes of Advanced Technology Chinese Academy of SciencesCBTN Data
Lead Institution
Shenzhen Institutes of Advanced Technology, Chinese Academy of Science
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MI-ONCOSEQ DMG Study

Lead Researcher
Carl Koschmann, MD
Lead Institution
Michigan Medicine C.S. Mott Children’s Hospital
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