PNOC and SJCRH Collaborative DIPG Radiogenomic Investigation

Semiquantitative imaging parameters extracted from magnetic resonance imaging (radiomics) have been suggested as a means to both identify and better characterize tumor biology and molecular features. We aim to define the relationship between quantitative and qualitative imaging features and molecularly defined subtypes of pediatric brainstem glioma and to evaluate the relationship between longitudinal changes in tumor and tumor habitat/subregion volumetric changes over time and patient-derived liquid biopsy specimens.