Molecular Characterization of Pediatric Brain Tumor Subjects and Trios within the Pediatric Brain Tumor Atlas
Lead Researcher
Mateusz Koptyra, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Diversity, Equity, and Inclusion: Translation of Informed Consent Forms
Lead Researcher
Cassie Kline, MD, MAS
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Discovering Novel Epigenetic Dependencies in Pediatric High-grade Glioma
Lead Researcher
Mariella Filbin, MD, PhD
Lead Institution
Harvard Medical School
Status
Active
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Disclosing Chromatin Accessibility in Brain Tumor Cells after Treatment by Cracking a ‘Nucleosomal Code’
Lead Researcher
Jakub Mieczkowski, PhD
Lead Institution
Medical University of Gdansk
Status
Active
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DIPG International Prevalence of Germline Mutations (DIPG-M)
Lead Researcher
Mark Pinese, PhD
Lead Institution
Children's Cancer Institute
Status
Active
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Cell Ecosystem and Signaling Pathways of Primary and Metastatic Pediatric Posterior Fossa Ependymoma
Lead Researcher
Pablo G. Cámara, PhD, DABMGG
Lead Institution
University of Pennsylvania
Status
Active
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Biomarker Identification for Neurofibromatosis Type 2 Background
Lead Researcher
Andrew Mullen, PhD
Lead Institution
NF2 Biosolutions and General Metabolics, LLC
Status
Active
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specimen
Comparison of Fusion Calling Platforms in Pediatric DIPG and High‐grade Glioma
Lead Researcher
Carl Koschmann, MD
Lead Institution
Michigan Medicine C.S. Mott Children’s Hospital
Status
Active
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Exploration of IDO1 as a Therapeutic Target in Pediatric Central Nervous System Tumors
Lead Researcher
Rishi Ramesh Lulla, MD
Lead Institution
The Warren Alpert Medical School of Brown University
Status
Complete
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Neurocytoma WGS and RNAseq
Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Complete
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Developing a Novel Tumor Model to Screen for New Therapies for Spinal Ependymoma
Lead Researcher
Linda M. Smith-Resar, MD
Lead Institution
Johns Hopkins Medicine
Status
Active
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specimen
Target Identification and Modeling of NF1-associated Low-grade Glioma
Lead Researcher
Michael J. Fisher, MD
Lead Institution
Children’s Hospital of Philadelphia
Status
Complete
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specimen
Targeting Replicative Stress in Pediatric Brain Tumors with ALT
Lead Researcher
Kristina A. Cole, MD, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Gene Expression Analysis Platform Evaluation for FFPE Specimen Material-Based Studies
Lead Researcher
Mateusz Koptyra
Lead Institution
Children's Hospital of Philadelphia
Status
Complete
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Evaluation of Immunosignature Profile in Medulloblastoma
Lead Researcher
Mateusz Koptyra, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Complete
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specimen
Whole Genome Sequencing and RNA Sequencing of the CBTN Bank for the Pediatric Brain Tumor Atlas
Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Proteogenomic Identification of Structural Variations
Lead Researcher
Brian Rood, MD
Lead Institution
Children’s National Hospital
Status
Active
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Comprehensive Molecular Analysis of Pediatric Thalamic tumors
Lead Researcher
Javad Nazarian, PhD, MSc
Lead Institution
Children’s National Hospital
Status
Active
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Development of the Ganglioside GD2 as a Biomarker and Clinical Trial Endpoint for Childhood Cancers
Lead Researcher
Frank M. Balis, MD
Lead Institution
Children’s Hospital of Philadelphia
Status
Complete
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Integrative Functional Genomics of Recurrent Childhood Medulloblastoma
Lead Researcher
Javad Nazarian, PhD, MSc
Lead Institution
Children’s National Hospital
Status
Active
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DIPG and Other Primary Pediatric Brain Tumors
Lead Researcher
Hideho Okada, MD, PhD
Lead Institution
UCSF Benioff Children’s Hospital
Status
Active
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Immunotherapeutically-targeting IDO1 in Pediatric High-grade Glioma
Lead Researcher
Derek Wainwright, PhD
Lead Institution
Northwestern University
Status
Complete
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Analysis of Chromatin Pathways as Regulators of High Grade Glioma Gene Expression Patterns
Lead Researcher
Jamie Anastas, PhD
Lead Institution
Boston Children's Hospital
Status
Active
Details
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Telomere Maintenance Across Multiple Brain Tumors
Lead Researcher
Kristina A. Cole, MD, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
Details
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In Silico Neo-antigen Detection in High-grade Pediatric Brain Tumors Utilizing RNA-seq and WGS
Lead Researcher
Peter Madsen, MD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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specimen
Choroid Plexus Tumor (CPT) Therapies Based on Patient-derived Cell Culture Resources
Lead Researcher
Mark Souweidane, MD
Lead Institution
Weill Cornell Medicine
Status
Active
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specimen
Identifying Tumor Cell Vulnerabilities in Recurrent/Progressive Human Medulloblastomas by Single-cell RNA-seq
Lead Researcher
Ninib Baryawno, PhD
Lead Institution
Karolinska Institutet
Status
Active
Details
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Spatial Evolution and Somatic Mutations Spectrum of Gliomatosis Cerebri
Lead Researcher
Jeffrey Greenfield, MD, PhD
Lead Institution
Weill Cornell Medicine
Status
Active
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Multi-Tensor Decompositions for Personalized Pediatric Glioma Diagnostics and Prognostics
Lead Researcher
Sri Priya Ponnapalli, PhD
Lead Institution
Eigengene
Status
Complete
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Integrative Analysis of Childhood Cancers
Lead Researcher
Charlie Vaske, PhD
Lead Institution
NantOmics
Status
Active
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Defining the Mutational Landscape of Pediatric Brain Tumors
Lead Researcher
Sharon J. Diskin, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Fusion Analysis in CBTN RNAseq Data
Lead Researcher
Andrea Sboner, PhD
Lead Institution
Weill Cornell Medicine
Status
Active
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Cooperating Mutations in Brain Tumors of Patients with NF1
Lead Researcher
Thomas De Raedt, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Genetic Polymorphisms and Neuro-Cognitive Outcomes in Pediatric Brain Tumor Survivors
Lead Researcher
Matthew Hocking, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Molecular Analysis of the Cellular Ecosystem of Childhood Ependymoma
Lead Researcher
Pablo G. Cámara, PhD, DABMGG
Lead Institution
University of Pennsylvania
Status
Active
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GPC2 as an Immunotherapeutic Target in Medulloblastoma and Other Pediatric Brain Tumors
Lead Researcher
Kristopher Bosse, MD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Treehouse Childhood Cancer Initiative: Identification of Therapeutic Leads for Individual Pediatric Cancer Patients via Cancer Analysis
Lead Researcher
David Haussler, PhD
Lead Institution
UC Santa Cruz Treehouse Childhood Cancer Initiative
Status
Active
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Comparison of Clinical Targeted Next Generation Sequencing (NGS) in FFPE with Whole Genome Sequencing (WGS) of Snap Frozen Pediatric Brain Tumors
Lead Researcher
Bonnie L. Cole, MD
Lead Institution
Seattle Children’s Hospital
Status
Active
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Cancer Predisposition in Pediatric Brain Tumors
Lead Researcher
Suzanne P. MacFarland, MD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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specimen
Interactions Between Astrocytes and Tumor Cells Are Critical for Medulloblastoma Growth
Lead Researcher
Suzanne P. MacFarland, MD
Lead Institution
Temple University
Status
Active
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Genomic Landscape of Mixed Glial Neuronal Tumors
Lead Researcher
Lea F. Surrey, MD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Cracking the Histone Code: Characterizing Pediatric Brain Tumor Epigenetics using Cerebrospinal Fluid
Lead Researcher
Amanda M. Saratsis, MD
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
Status
Active
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Identifying New Cell Surface Targets for Immunotherapy Treatment of Poor Prognosis Pediatric Brain Tumors
Lead Researcher
Misty Jenkins, PhD
Lead Institution
Walter and Eliza Hall Institute of Medical Research (WEHI)
Status
Active
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Immunogenomic Landscape of Pediatric Cancers
Lead Researcher
Trevor Pugh, PhD, FACMG
Lead Institution
University of Toronto
Status
Active
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Identify Novel Therapeutic Targets and Biomarkers in Non-coding Genome of Pediatric Cancers
Lead Researcher
Lihua Zou, PhD
Lead Institution
Northwestern University
Status
Active
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Children’s Brain Tumor Network Pediatric Brain Tumor Proteomics Pilot
Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Deciphering the Molecular Characteristics of Pediatric Meningiomas
Lead Researcher
Nadia Dahmane, PhD
Lead Institution
Weill Cornell Medicine
Status
Active
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Characterizing the Prevalence of ETMR by Molecular Signature
Lead Researcher
Derek Hanson, MD
Lead Institution
Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center
Status
Active
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specimen
Development of Preclinical Models of Pediatric Ependymoma
Lead Researcher
Ching Ching Lau, MD, PhD
Lead Institution
Hematology-Oncology at Connecticut Children’s
Status
Active
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Comprehensive Genomic and Immune Signature Profiling of Ependymoma and Diffuse Intrinsic Pontine Glioma
Lead Researcher
Kathleen M. Schieffer, MLS
Lead Institution
Nationwide Children's Hospital
Status
Active
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Detection of Cooperative and Mutually Exclusive Genetic Alterations in Pediatric Cancer
Lead Researcher
Patrick Kemmeren, PhD
Lead Institution
Princess Maxima Center for Pediatric Oncology
Status
Active
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Genomic Correlates with Radiation Injury
Lead Researcher
Oren J. Becher, MD
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
Status
Active
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Predictive Models for Transcriptome Variations
Lead Researcher
Yoseph Barash, PhD
Lead Institution
University of Pennsylvania
Status
Active
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specimen
Pediatric Brain Tumor miRNA Profiling for the Cohort of Children’s Brain Tumor Network Specimens
Lead Researcher
Mateusz Koptyra, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Hudson Monash Paediatric Precision Medicine Program
Lead Researcher
Ron Firestein, MD, PhD
Lead Institution
Hudson Institute of Medical Research
Status
Active
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specimen
Elucidating the Somatic Epigenetic Landscape of Pediatric Meningioma and Schwannoma
Lead Researcher
Sameer Agnihotri, PhD
Lead Institution
UPMC Children’s Hospital of Pittsburgh
Status
Active
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Center for Pediatric Tumor Cell Atlas
Lead Researcher
Kristina A. Cole, MD, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Germline mtDNA Variants and Somatic mtDNA Mutations in Pediatric Brain Tumors
Lead Researcher
Xiaowu Gai, PhD
Lead Institution
Children's Hospital Los Angeles
Status
Active
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specimen
Project Hope: High-Grade Glioma-Omics in Pediatric and AYA
Lead Researcher
Adam Resnick, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Pediatric Brain Tumor Classification and Segmentation Using Transfer Learning from Adult Datasets
Lead Researcher
Roy H. Campbell, PhD
Lead Institution
University of Illinois
Status
Active
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data
Alternative Splicing in CBTN Data
Lead Researcher
Shihao Shen, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
Details
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data
Relationships Between Genomic, Imaging, and Histopathologic Characteristics in Pediatric Brain Tumors
Lead Researcher
Benjamin Hartley, MD
Lead Institution
Weill Cornell Medicine
Status
Active
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Discover New Therapeutics for DIPG using a Systems-Based Approach
Lead Researcher
Bin Chen, PhD
Lead Institution
Michigan State University
Status
Active
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Comprehensive Analysis of Structural Variants in Pediatric Brain Tumors
Lead Researcher
Lixing Yang, PhD, MSc
Lead Institution
University of Chicago
Status
Active
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Clinical, Radiologic, and Molecular Characteristics of Anaplastic Pleomorphic Xanthoastrocytomas
Lead Researcher
Alberto Bronisco, MD, MS
Lead Institution
UPMC Children's Hospital of Pittsburgh
Status
Active
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Central Nervous System Cancers in Patients with Non-Neurofibromatosis Type 1 RASopathies
Lead Researcher
Alberto Bronisco, MD, MS
Lead Institution
UPMC Children's Hospital of Pittsburgh
Status
Active
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Molecular Characterization of Choroid Plexus Tumors
Lead Researcher
Christian Thomas, MD
Lead Institution
Institute of Neuropathology Münster
Status
Active
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Germline and Somatic Microsatellite Genotypes in Pediatric Brain Tumors
Lead Researcher
Brian Rood, MD
Lead Institution
Children’s National Hospital
Status
Active
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Epigenetic Drivers in Medulloblastoma
Lead Researcher
Alexandros Tzatsos, MD, PhD
Lead Institution
George Washington University
Status
Active
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Epigenetic Drivers in Diffuse Intrinsic Pontine Gliomas (DIPG)
Lead Researcher
Alexandros Tzatsos, MD, PhD
Lead Institution
George Washington University
Status
Complete
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Descriptive “Pharmacogenomics Analysis” of the CBTN PBTA Cohort
Lead Researcher
Angela Waanders, MD, MPH
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
Status
Active
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Comparison of CBTN Patient Data with Molecularly-Defined Stem Cell Models of Pediatric Brain Tumors
Lead Researcher
Fredrik Swartling, PhD
Lead Institution
Uppsala University, SWEDEN
Status
Active
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Body Mass Index Trajectories in Craniopharyngioma
Lead Researcher
Shana McCormack, MD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Landscape of Tumor-infiltrating T-Cell Repertoire of Pediatric Brain Tumors
Lead Researcher
Gary Kohanbash, PhD
Lead Institution
UPMC Children’s Hospital of Pittsburgh
Status
Active
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Evaluating the Landscape of Compound Heterozygous Variants in Pediatric Diseases
Lead Researcher
Stephen Piccolo, PhD
Lead Institution
Brigham Young University
Status
Active
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PNOC and SJCRH Collaborative DIPG Radiogenomic Investigation
Lead Researcher
John Lucas, MD, MS
Lead Institution
St. Jude Children's Research Hospital
Status
Active
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Molecular and Functional Characterization of Childhood Supratentorial Ependymoma
Lead Researcher
Vijay Ramaswamy, MD, PhD, FRCPC
Lead Institution
Sick Kids
Status
Active
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specimen
Genomic Analysis of Oligodendrogliomas Across Pediatrics, Adolescents and Adults
Lead Researcher
Adam Resnick PhD PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Cancer Stemness of Pediatric Tumors
Lead Researcher
Maciej Wiznerowicz, MD, PhD
Lead Institution
International Institute for Molecular Oncology
Status
Active
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Targeting Immunosuppressive Macrophage in Pediatric Brain Tumors
Lead Researcher
Erin Crotty, MD
Lead Institution
Seattle Children's Hospital
Status
Active
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Detecting Gene Fusions and Subtype Discovery in Pediatric Solid Tumors RNA-Seq using CICERO
Lead Researcher
Scott Newman, PhD
Lead Institution
St. Jude Children's Research Hospital
Status
Active
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Defining the Global Impact of Somatic Structural Variation on the Transcriptome of Human Pediatric Brain Cancers
Lead Researcher
Chad Creighton, PhD
Lead Institution
Baylor College of Medicine
Status
Active
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specimen
Oncolytic Virus to Potentiate Immune-checkpoint Blockade in Immunologically Cold Pediatric Brain Tumors
Lead Researcher
Aaron Diaz, PhD
Lead Institution
UCSF Benioff Children’s Hospital
Status
Active
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specimen
Germline and Somatic Determinants of Paediatric Brain Tumor Evolution
Lead Researcher
Sorana Morrissy, PhD
Lead Institution
University of Calgary
Status
Active
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specimen
Exploring the Possible Role of Mutations in MTOR pathway Genes in the Pathogenesis of DNET Tumors
Lead Researcher
Anna Maria Buccoliero, MD, PhD
Lead Institution
Meyer Children’s Hospital
Status
Active
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Cross-disease Variant Lookup in CBTN
Lead Researcher
Yiran Guo, PhD
Lead Institution
Children's Hospital of Philadelphia
Status
Active
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specimen
Elucidating the Role of Driver Mutations in Pediatric High Grade Glioma
Lead Researcher
Thomas De Raedt, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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specimen
Elucidate Potential Therapeutic Targets in H3.3G34 Mutant pHGG Cells
Lead Researcher
Zhiguo Zhang, PhD
Lead Institution
Columbia University
Status
Active
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specimen
CBTN Cell Lines High-Throughput Drug Screening Study (NCATS)
Lead Researcher
Mateusz Koptyra, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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Genomics of Radiation-induced Cavernomas in Pediatric Tumor Patients
Lead Researcher
YouRong Sophie Su MD, DO
Lead Institution
University of Pennsylvania
Status
Active
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Comprehensive Molecular Profiling of Pediatric Meningioma
Lead Researcher
Kathleen M. Schieffer, MLS
Lead Institution
Nationwide Children's Hospital
Status
Active
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Multi-scale Model of Children with Brain Tumors
Lead Researcher
Olivier Gevaert, PhD
Lead Institution
Stanford University
Status
Active
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The Australian Bioinformatics Commons Paediatric Cancer Pathfinder Project
Lead Researcher
Mark Cowley, BSc, PhD
Lead Institution
Children's Cancer Institute
Status
Active
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Developing Summative Measures of Paediatric Cancer Risk
Lead Researcher
Mark Cowley, BSc, PhD
Lead Institution
Children's Cancer Institute
Status
Active
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Decoding the Dark Matter of the High-Risk Paediatric Cancer Genome
Lead Researcher
Mark Cowley, BSc, PhD
Lead Institution
Children's Cancer Institute
Status
Active
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Investigating Biomarker for Treatment Respondors and Non-respondors in PDX Model Experiment
Lead Researcher
Mi-Youn Brusniak PhD, PMP
Lead Institution
Fred Hutchinson Cancer Recerch Center
Status
Active
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Comprehensive Molecular Profiling of Pediatric Diffuse Astrocytomas: Independent Validation of Proteomic Analysis
Lead Researcher
Kathleen M. Schieffer, MLS
Lead Institution
Nationwide Children's Hospital
Status
Active
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A Highly-Usable and Fully-Comprehensive Proteogenomic Method Leveraging the Breadth of Genetic Variation for Oncogenic and/or Therapeutic Novel Protein Discovery
Lead Researcher
Alex Kentsis, MD PhD
Lead Institution
Memorial Sloan-Kettering Cancer Center
Status
Active
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Novel Neoantigen Detection from Complex Transcriptomic Structures in Pediatric Brain Tumors
Lead Researcher
Tamer Ahmed, MD, PhD
Lead Institution
University of California - Davis
Status
Active
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Defining the Role of the Histone 3 (H3.3G34R) Mutation in the Pathogenesis of Pediatric High Astrocytoma
Lead Researcher
Cynthia Hawkins, MD, PhD, FRCPC
Lead Institution
Sick Kids
Status
Active
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specimen
Microglial Mosaicism in BRAFV600E Glioma Development
Lead Researcher
Estibaliz Lopez-Rodrigo, MD
Lead Institution
Weill Cornell Medicine
Status
Active
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Therapeutic Targeting of the Blood-Brain Barrier in Pediatric Malignant Brain Tumors
Lead Researcher
Sadhana Jackson, MD
Lead Institution
National Cancer Institute, National Institute of Health
Status
Active
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specimen
Targeting Medulloblastoma by Regulating RNA Binding Proteins
Lead Researcher
Robert Schnepp, MD, PhD
Lead Institution
Emory University
Status
Active
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specimen
Released Tumor DNA in the CSF for the Diagnosis and Monitoring of Pediatric Brain Tumors
Lead Researcher
Chetan Bettegowda, MD, PhD
Lead Institution
Johns Hopkins Medicine
Status
Active
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Mitochondrial Mutations in Pediatric Brain Cancer
Lead Researcher
Paul Boutros, Ph.D., M.B.A
Lead Institution
University of California, Los Angeles
Status
Active
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Splicing Analysis in Ependymoma
Lead Researcher
Marcel Kool, PhD
Lead Institution
Hopp Children's Cancer Center
Status
Active
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specimen
Regional Response to ONC201 in Pediatric High-Grade Glioma
Lead Researcher
Carl Koschmann, MD
Lead Institution
Michigan Medicine C.S. Mott Children’s Hospital
Status
Active
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specimen
Using Whole Genome Bisulfite Sequencing to Identify Novel Therapeutic Targets in DIPG and ATRT
Lead Researcher
Eric Raabe, MD, PhD
Lead Institution
Johns Hopkins Medicine
Status
Active
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The Role of Mutational Signatures in the Development of Childhood Cancer
Lead Researcher
Michael E. Scheurer, PhD, MPH, FACE
Lead Institution
Baylor College of Medicine
Status
Active
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iPC EU Horizon 2020 – Individualized Paediatric Cure: Cloud-based Virtual-patient Models for Precision Paediatric Oncology
Lead Researcher
Dejan Stepec, MS
Lead Institution
XLAB d.o.o.
Status
Active
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Exploring the Somatic Landscape of Adult and Paediatric Chordoma
Ann & Robert H. Lurie Children’s Hospital of Chicago
Status
Active
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specimen
Impeding LIN28 Function in ATRT
Lead Researcher
Giselle Saulnier Sholler, MD
Lead Institution
Levine Children's Cancer & Blood Disorders
Status
Active
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Mechanistic Modeling of High-grade Glioma
Lead Researcher
Dr Christoph Wierling
Lead Institution
Alacris Theranostics GmbH
Status
Active
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The Role of Genetic Factors in Ependymoma Susceptibility
Lead Researcher
Maral Adel Fahmideh, PhD
Lead Institution
Baylor College of Medicine
Status
Active
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specimen
Identification of Circulating Noncoding RNAs and Metabolites in Cerebrospinal Fluid(CSF) in Medulloblastoma Patients
Lead Researcher
Ranjan Perera, PhD
Lead Institution
Johns Hopkins Medicine
Status
Active
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specimen
Circular RNAs in Medulloblastoma
Lead Researcher
Peter George Zaphiropoulos, PhD
Lead Institution
Karolinska Institutet
Status
Active
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Cross-Species Omics Integration to Identify Oncogenic Events in Pediatric Brain Tumors
Lead Researcher
Junmin Peng, PhD
Lead Institution
St. Jude Children's Research Hospital
Status
Active
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Proteomic Analysis of CBTN Cell Lines
Lead Researcher
Roger Reddel, MD, BSc (Med), MBBS, FRACP, FAAHMS, FAA
Lead Institution
The University of Sydney
Status
Active
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Brain Match
Lead Researcher
Stefan M. Pfister, MD
Lead Institution
Hopp Children's Cancer Center
Status
Active
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specimen
Investigating Disease Mechanism In Adamantinomatous Craniopharyngioma Using New Cell Line Models
Lead Researcher
Todd Hankinson, MD
Lead Institution
Children's Hospital of Colorado
Status
Active
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Pediatric Pan-Cancer Analysis of Structural Variants
Lead Researcher
Lukas Chavez, PhD
Lead Institution
University of California, San Diego
Status
Active
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Genetic Variability Across Major Histocompatibility Complex
Lead Researcher
Tristan J Hayeck, PhD
Lead Institution
Children's Hospital of Philadelphia
Status
Active
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A Study of Outcomes in Patients with CNS Tumors with BCOR Mutations
Lead Researcher
Scott Raskin, DO
Lead Institution
Children's National Hospital
Status
Active
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Determining Prognostic Factors and Genetic Markers that Impact Survival in Recurrent Pediatric Medulloblastoma
Lead Researcher
Chetan Bettegowda, MD, PhD
Lead Institution
Johns Hopkins Medicine
Status
Active
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Sex-specific Gene Expression Signatures in Pediatric Brain Tumors
Lead Researcher
Joshua B. Rubin, MD, PhD
Lead Institution
St. Louis Children’s Hospital
Status
Active
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Non-coding Genetic Events in Medulloblastoma and Ependymoma
Lead Researcher
Marco Gallo, PhD
Lead Institution
University of Calgary
Status
Active
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Genetic Architecture of Molecular Phenotypes in Pediatric Brain Cancers
Lead Researcher
Sebastian Waszak, PhD
Lead Institution
University of Oslo
Status
Active
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Mechanisms of Medulloblastoma Formation
Lead Researcher
Erwin G. Van Meir, PhD
Lead Institution
University of Alabama at Birmingham (UAB)
Status
Active
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Targeting Regions of Converging Synteny in Pediatric and Canine Glioma
Lead Researcher
Roel Verhaak, PhD
Lead Institution
The Jackson Laboratory
Status
Active
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specimen
Investigating the Metabolic Hallmarks of Oligodendroglioma
Lead Researcher
Samuel McBrayer, PhD
Lead Institution
Children’s Medical Center Research Institute at UT Southwestern
Status
Active
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data
Artificial Intelligence for Pediatric Brain Tumor Detection and Prediction of Disease Progression
Lead Researcher
Patrick Hales, PhD
Lead Institution
University College London
Status
Active
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Investigating the Immune Response in Pediatric Glioma Subsets
Lead Researcher
Joanna Phillips MD, PhD
Lead Institution
UCSF Benioff Children’s Hospital
Status
Active
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data
Detecting Driver Mutations of Central Nervous System Germ Cell Tumors
Lead Researcher
Jiguang Wang, PhD
Lead Institution
HONG KONG University of Science and Technology
Status
Active
Details
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Aberrant Splicing Candidates as Potential Neoantigen Expression in High-grade Glioma
Lead Researcher
Patrick Pirrotte, PhD
Lead Institution
Translational Genomics Research Institute
Status
Active
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Aberrant Splicing Candidates as Potential Neoantigen Expression in HGG
Lead Researcher
Patrick Pirrotte, PhD
Lead Institution
The Translational Genomics Research Institute
Status
Active
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data
Searching for Differences in Molecular Profile of Pediatric Gliomas
Lead Researcher
Nikolay Ivanov, BS
Lead Institution
Weill Cornell Medicine
Status
Active
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data
Identifying the Cells of Origins of Brain Tumors Using Somatic Mutations
Lead Researcher
Gilad Evrony, MD, PhD
Lead Institution
Hassenfeld Children’s Hospital at NYU Langone
Status
Active
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specimen
Delineating Pediatric Glioma Progression Using Single-nuclei Sequencing
Lead Researcher
Trevor Pugh, PhD, FACMG
Lead Institution
University of Toronto
Status
Active
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Structural Variants in Human and Canine Cancer Datasets
Lead Researcher
Charles Lee, Ph.D., D.Sc., FACMG, FRSC
Lead Institution
The Jackson Laboratory
Status
Active
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data
Targeting Master Regulator Dependencies in Diffuse Intrinsic Pontine Glioma (DIPG)
Lead Researcher
Javad Nazarian,PhD, MSc
Lead Institution
Children’s National Hospital
Status
Active
Details
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specimen
Personalized Therapy for High-risk Ependymoma of Childhood
Lead Researcher
Vijay Ramaswamy, MD, PhD, FRCPC
Lead Institution
Sick Kids
Status
Active
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specimen
Functional Dependency Mapping in Paediatric Brain Cancers
Lead Researcher
Ron Firestein, MD, PhD
Lead Institution
Hudson Institute of Medical Research
Status
Active
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Precision Imaging of Pediatric High-grade Gliomas with Quantitative Diffusion Weighted Imaging and Texture Analysis to Identify Imaging Biomarkers That Predict Tumor Genetics and Patient Outcomes
Lead Researcher
Mariam Aboian, MD, PhD
Lead Institution
Yale School of Medicine
Status
Active
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specimen
Use of Ependymoma Cell Lines to Test for New Therapeutic Vulnerabilities
Lead Researcher
Marcel Kool, PhD
Lead Institution
Hopp Children's Cancer Center
Status
Active
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Development of a New Therapy Against Diffuse Intrinsic Pontine Glioma
Lead Researcher
Terrance Johns, PhD
Lead Institution
The University of Western Australia
Status
Active
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data
Identification of Novel Therapeutic Approaches for pHGGs
Lead Researcher
Massimo Squatrito, PhD
Lead Institution
Spanish National Cancer Research Center (CNIO)
Status
Active
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data
A Comparison of Hallmark Mutations in Pediatric and Adult Brain Tumors
Lead Researcher
Kevin D Judy, MD
Lead Institution
Thomas Jefferson University Hospital
Status
Active
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Leveraging Existing Pediatric Low-Grade Tumor Specimens, Clinical and Imaging Outcome Data, and Artificial Intelligence Innovations to Develop Integrated Biomarkers of Response for Children With Low-Grade Glioma
Lead Researcher
Benjamin H. Kann, MD
Lead Institution
Harvard Medical School
Status
Active
Details
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Landscape of Germline Histone Mutations in Pediatric Brain Tumor Patients
Lead Researcher
Javad Nazarian, PhD, MSc
Lead Institution
Children’s National Hospital
Status
Active
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specimen
Oncogene-Induced Senescence in RTK-fused Infant High Grade Gliomas
Lead Researcher
David Kram, MD, MCR
Lead Institution
UNC Chapel Hill – North Carolina Children’s Hospital
Status
Active
Details
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Characterizing the Blood-Brain-Barrier in Pediatric Brain Tumors
Lead Researcher
Nadia Dahmane
PhD
Lead Institution
Weill Cornell Medicine
Status
Active
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Analyze the Relationship Between the Expression of Specific Genes and the Prognosis in Pediatric Gliomas
Lead Researcher
Feng Wan, MD
Lead Institution
Tongji Hospital, Tongji Medical College, Huazhong University of Science and
Technology
Status
Active
Details
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specimen
Investigating the Tumorigenesis Mechanisms and Vulnerabilities of Pediatric High-grade Gliomas with H3G34R/V
Lead Researcher
Yang Shi, PhD
Lead Institution
Harvard Medical School
Status
Active
Details
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specimen
Genetic Vulnerabilities in Supratentorial and Infratentorial Pediatric High-grade Gliomas
Lead Researcher
Massimo Squatrito, PhD
Lead Institution
Spanish National Cancer Research Center (CNIO)
Status
Active
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specimen
MET Alterations in DMGs
Lead Researcher
Payal Jain, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
Details
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Pediatric Meningiomas
Lead Researcher
Sameer Agnihotri, PhD
Lead Institution
UPMC Children’s Hospital of Pittsburgh
Status
Active
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Molecular Mechanisms and Functional Impact of Aberrant Splicing in Diffuse Midline Gliomas
Lead Researcher
Ammar Naqvi, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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specimen
Elucidating Heterogeneity of Resistance Across Molecular Subgroups of Pediatric Ependymomas to Inform Future Therapeutics
Lead Researcher
Jeffrey Greenfield, MD, PhD
Lead Institution
Weill Cornell Medicine
Status
Active
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Correlating Genomic Features with the Immune Microenvironment in Pediatric Glioma
Lead Researcher
Robyn Gartrell, MD, MS
Lead Institution
Columbia University
Status
Active
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The Landscape of Pediatric RTK-Driven Gliomas
Lead Researcher
Ana Guerreiro Stücklin, MD, PhD
Lead Institution
University Children’s Hospital Zürich
Status
Active
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Radiogenomic Analysis of Pediatric Brain Tumors
Lead Researcher
Pallavi Tiwari, PhD, MS
Lead Institution
Case Western Reserve University
Status
Active
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Genetic Risk Factors for Pediatric Brain Tumors
Lead Researcher
Anna Dahlin
Lead Institution
Umeå University
Status
Active
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Immune Receptor Recombinations in Childhood Brain
Lead Researcher
George Blanck, PhD
Lead Institution
University of South Florida
Status
Active
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Targeting Histone H3K4me3 for the Treatment of Pediatric Gliomas
Lead Researcher
Guifa Xi, MD, PhD
Lead Institution
Ann & Robert H. Lurie Children’s Hospital of Chicago
Status
Active
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specimen
RP58 and SMARCB1 in AT/RT Pathogenesis
Lead Researcher
Nadia Dahmane, PhD
Lead Institution
Weill Cornell Medicine
Status
Active
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specimen
Evaluation of Drug Vulnerability of NF2 Tumor Models
Lead Researcher
Joseph Kissil, PhD
Lead Institution
Moffitt Cancer Center
Status
Active
Details
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Germline Determinants of the Pediatric Tumor Immune Microenvironment
Lead Researcher
Hannah Carter, PhD
Lead Institution
University of California, San Diego
Status
Active
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Investigating the Etiology of Genomic Rearrangements in Human Cancers
Lead Researcher
Xiaotu Ma, PhD
Lead Institution
St. Jude Children's Research Hospital
Status
Active
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specimen
Pre-clinical Studies for NF2 Schwannomas
Lead Researcher
Christina Fernandez-Valle, PhD
Lead Institution
University of Central Florida
Status
Active
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specimen
CDC42 RHOJ Interaction Inhibitors for the Treatment of Neurofibromatosis
Lead Researcher
Anand Ganesan, MD, PhD
Lead Institution
University of California, Irvine
Status
Active
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Using Histopathology to Discover Genetic Alterations in Pediatric Brain Tumors
Lead Researcher
Sabine Mueller, MD, PhD
Lead Institution
UCSF Benioff Children’s Hospital
Status
Active
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High Dimensional Protein Characterization of Tumor Tissues and Relevance to Outcomes in Immunotherapy Clinical Trials
Lead Researcher
Kristina A. Cole, MD, PhD
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
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specimen
Establishing a Thalamic Glioma Model
Lead Researcher
Javad Nazarian, PhD, MSc
Lead Institution
Children’s National Hospital
Status
Active
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specimen
Novel Platforms for Developing Therapies for Transformed Gliomas in Patients with NF1
Lead Researcher
Javad Nazarian, PhD, MSc
Lead Institution
Children’s National Hospital
Status
Active
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specimen
Evaluating NF2 and Other Tumor Disease Mechanisms
Lead Researcher
Javad Nazarian, PhD, MSc
Lead Institution
Children’s National Hospital
Status
Active
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Elucidating the ETMR Microenvironment Using Next Generation Imaging and Multi-omics Technologies
Lead Researcher
Claire Carter, PhD
Lead Institution
Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center
Status
Active
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Multi-Institutional Analysis of Recurrent Central Nervous System Germinomas
Lead Researcher
Mohamed AbdelBaki, MD
Lead Institution
St. Louis Children’s Hospital
Status
Complete
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specimen
Development of CAR-T Cell Therapy for Atypical Teratoid/Rhabdoid Tumors
Lead Researcher
Peter Madsen, M.D.
Children’s Hospital of Philadelphia
Philadelphia, PA, USA
CBTN Specimen
Lead Institution
Children’s Hospital of Philadelphia
Status
Active
Details
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Comparison of RNA-Binding Protein Expressions in Pediatric and Adult Glioblastoma
Lead Researcher
ZHU Xinzhou, PhDShenZhen Institutes of Advanced Technology Chinese Academy of SciencesCBTN Data
Lead Institution
Shenzhen Institutes of Advanced Technology, Chinese Academy of Science