Characterize the immune microenvironment of DMG using single-cell based deconvolution approaches

Diffuse midline gliomas (DMGs) are brain malignancies that are highly aggressive, challenging to treat, and remain one of the leading causes of morbidity and mortality in pediatric patients. Understanding the underlying cellular and molecular components is critical for developing novel therapeutic strategies. Our approach is expected to validate the use of deconvolution analysis of CBTN bulk genomic data to profile the tumor immune microenvironment and aid in the stratification of patients, as well as design of effective immunotherapeutic strategies for DMGs.