circRNA atlas of pediatric brain tumors

Circular RNAs (circRNAs) are a type of RNA which is in a circular form and resistant to degradation. circRNAs have been shown to be involved in many different functions of cancer such as tumor initiation, progression or metastasis. In the past, we have used circRNAs to correctly identify subgroups of medulloblastoma which were previously assigned groups using an expensive multi-layer approach involving mass spectrometry proteomics, RNA sequencing transcriptomics and DNA methylation profiling.
In this analysis, we would like to analyze different types of brain tumors to see if they are all similar or different from each other using circRNAs. In a previous experiment, we noticed that different tumor types tend to stick together. Using circRNAs from the different tumor types, we aim to identify biomarkers that will allow accurate identification of the tumor and, if possible, for the detection of the tumor using biofluids such as cerebral spinal fluid or blood.