Comprehensive Genomic and Immune Signature Profiling of Ependymoma and Diffuse Intrinsic Pontine Glioma

Brain tumors are the most common form of pediatric tumor, and while advancements have been made in treating a variety of tumor types, the need for comprehensive research into all pediatric brain tumors is great. Certain subtypes of ependymoma are associated with poor outcomes for patients as well as with diffuse intrinsic pontine glioma (DIPG) brain tumor patients. Both would benefit greatly from an expansion of comprehensive study of their genome. This study aims to do just that by taking an approach that combines genetic and epigenetic (non-gene) influences with data on immune response. The Pediatric Brain Tumor Atlas will give researchers access to a unique set of data necessary to carry out this research.