Defining the global impact of germline structural variation on the transcriptome of human pediatric brain cancers

By integrative analysis of germline SVs and gene expression data from pediatric brain cancers, we will identify genes for which the nearby presence of a germline SV breakpoint is associated with altered expression. Most of the significant genes by integrated germline SV-expression analysis would not necessarily have specific roles in cancer but would instead simply reflect germline variation. However, some genes may have known roles in cancer or also appear targeted by somatic SVs or have an association with cancer patient survival.