Elucidating the ETMR Microenvironment using Next Generation Imaging and Multi-omics Technologies

As there is known diversity in histologic features of ETMR tumors, we feel that it is important to characterize multiple tissue samples using our IMC and MSI techniques to truly define the landscape of the ETMR microenvironment. Due to the rarity of ETMR, there is a paucity of tissue specimens available for research. Therefore, the CBTN’s repository serves as an important resource for ETMR tissue as it contains multiple flash-frozen samples. As our techniques require only small amounts of tissue, we will be able to preserve the majority of these precious samples while obtaining novel, and hopefully impactful, information about this deadly tumor. This proposed project will only utilize the requested specimens from the CBTN. All ETMR cases from our institution were not banked locally and were instead sent to CBTN.