Evaluation of Drug Vulnerability of NF2 Tumor Models

NF2 tumors are very rare and understudied tumors. An important part of studying tumors is understanding how drugs interact with them. This proposal aims to explore 3000+ compounds on NF2 cell lines, samples derived from patients with NF2 tumors. Exploring the interactions of drugs with the tumor can highlight opportunities for new treatments. Part of the challenge in studying NF2 tumors is the availability of high quality specimens. There are very few cell lines available for use by researchers, making specimens made available through the Pediatric Brain Tumor Atlas invaluable to this work. The generated data may be the first of the type in the field and will establish drug vulnerability as well as potential targets/biomarkers specific to the NF2 tumors. The data generated from this study will help guide continued study of NF2 tumors and support the identification of new therapies.