Evolutionary trajectories of pediatric cancers

Whole-Genome Sequencing can be used to trace tumour evolutionary trajectories on an individual base. The role of such information is key to interpret the process of malignant transformation, how and when it starts, and we can counteract it from an evolutionary standpoint. The possibility of studying that in the pediatric context, with treatment-associated followup, is unique and the CBTN cohort is a unique asset in this respect.