FOXR2 driver events and clinical outcomes in CNS neuroblastoma with FOXR2 activation

The goal of this study is to identify cases of CNS neuroblastoma with FOXR2 activation and utilize tumor data, including changes in copy number, changes in RNA, changes in DNA, and methylation to identify the FOXR2-altering events that drive these tumors. Importantly, given this is a recent and newly identified type of brain tumor, there is limited clinical information on understanding how patients are treated, their outcomes, and whether these are related to specific changes in the tumor genome.