Genetic Risk Factors for Pediatric Brain Tumors

The association between germline genetic variants and risk of developing a brain tumor in childhood will be investigated using statistical analysis including cases of brain tumors (CBTTC/PNOC data) and control subjects. Analyses will be done separately for different subtypes of tumors. Results will be combined with results from other studies using meta-analysis. We will also use CBTTC/PNOC data to investigate how genetic variants are related to molecular characteristics in the tumor, for example somatic alterations, gene expression, and DNA methylation.