High dimensional protein characterization of tumor tissues and relevance to outcomes in immunotherapy clinical trials

This collaborative project by CBTTC and Parker Institute (PICI) investigators aims to examine the immune and tumor microenvironment in situ in pediatric brain tumor tissues, particularly in response to immunotherapy. Integration of single cell multiplex imaging of tissue microarray targets (TMAs) with existing orthogonal genomic, proteomic, and clinical datasets offer the hope of advancing immunotherapy approaches for pediatric brain tumors.