Identification of medulloblastoma metastases

Medulloblastoma is the most common malignant pediatric central nervous system tumor in children. Leptomeningeal metastasis is present at initial diagnosis 5-45% of patients depending on molecular subgroup and is an independent predictor of survival. It is currently unknown if medulloblastoma cells bind to the arachnoid, pia, or both. Determining this has putative therapeutic implications in the prevention and treatment of leptomeningeal metastasis. The objective of the present study is to characterize the location and attachment sites of leptomeningeal medulloblastoma metastases based on magnetic resonance imaging.