Integrated Genomic Analysis to elucidate the role of PIKC3A and 10q LOH as Unique drivers and cooperating events in pediatric high grade gliomas

Our analysis suggests that the PTEN/AKT/PIK3CA group represents a fourth distinct molecularly tractable entity that has a prognosis almost as poor as the K27M subset. Moreover, this pathway has not been explored as a stand alone, driver or as cooperating or exclusive events from other known entities of pHGG including the H3 (K27M, G34R/V), BRAF (V600E) and IDH1(R172H) groups.