Landscape of germline histone mutations in pediatric brain tumor patients

Recent studies have identified a link between germline histone mutations and an increased risk for developmental and neurological disorders, however few studies have investigated the landscape of germline histone mutations in diffuse midline glioma (DMG) and other pediatric CNS tumors. We propose to address this gap by investigating germline mutations affecting histone-encoding genes in pediatric CNS tumors, and in particular DMGs, from the CBTTC dataset.