Molecular and Functional Characterization of Paediatric Solid Tumours

The Childhood Cancer Model Atlas (CCMA) represents a pioneering effort aimed at cultivating pediatric cancer cell lines that faithfully mirror the molecular intricacies of various pediatric malignancies. Spearheaded by the Hudson Institute of Medical Research, this initiative has meticulously developed and characterized over 300 pediatric cancer models, yielding novel therapeutic strategies with clinical significance (Sun C., Daniel P., et al Cancer Cell). Our study goals are to use this resource to catalyse discoveries which will translate to better treatments for childhood cancer patients. To do this, we seek to expand our resource to include patient tissues from CBTN which we will perform targeted total proteomics to validate biomarker candidates for lead drug opportunities identified from our discovery pipeline.