Molecular Predictors of e-Radiation Resistance in H3K27M alerted diffuse midline gliomas

For our study, we will create both a clinical model, including genomic data and radiographic model to predict and risk stratify patients with H3K27M altered diffuse midline glioma (DMG) for re-radiation therapy. This study is significant because it will allow neuro oncologist to predict which patients may respond to re-radiation at progression and avoid further morbidity and complications for those that may not derive any benefit. We hope to integrate this model into the literature to change current radiation practices in neuro-oncology as it relates to H3K27M altered DMG.