Novel organoid model generation for transformed gliomas in patients with NF1

Our team is requesting CBTN specimens to help support our efforts in the above stated aim for our project. The Children’s National Hospital Brain Tumor Biorepository currently has one NF-1 cell line which was obtained from Eric Raabe (JHU), as well as several CBTN lines with somatic NF-1 mutations. We have developed the experience and expertise to culture cells for pre-clinical studies from both surgical and autopsy patient samples. The CBTN team has already demonstrated a high level of success in organoid development and our team would benefit from the not only obtaining samples but also in protocol development.