Oncogene-Induced Senescence in RTK-fused Infant High Grade Gliomas

CBTTC/CBTN tissue is crucial for this project, as iHGG is exceedingly rare. The tumor tissue bank of the Tumor Tissue and Pathology Shared Resource at Wake Forest Baptist Comprehensive Cancer Center has two RTK-fused iHGG (both babies are clinically in remission after gross-total resection alone, no adjuvant therapy administered), along with a very large cadre of adult glioma tissue, all of which we plan to use for this project. CBTTC/CBTN provides a large cohort of samples from children and young adults with brain tumors. Tissue from the CBTTC/CBTN will provide the needed specimens to increase the number of samples in each infant/pediatric group, namely the iHGG, pLGG, and pHGG groups. In addition, the iHGG cell lines derived from patients without RTK fusions will provide us with a tool for analyzing the effect of RTK fusion protein overexpression on senescence and tumorigenesis. We currently do not intend to request any specimens from other outside sources for this project.