Splicing Analysis in Ependymoma

The focus of this project is on ependymoma, a pediatric brain tumor with various subtypes. The drivers of each of these subtypes and drug targets for treatments in these types have not been identified. Changes in the genome, called genetic alterations, are known to have pivotal roles in the development and progression of cancers. One form of gene alteration that takes place in cancers are transcript isoforms. The goal of this project is to identify transcript isoforms that are only present in specific subtypes of ependymoma. This insight could lead to better treatment options and a better outcome for patients. To complete this important work, researchers will access the ependymoma data represented in the Pediatric Brain Tumor Atlas.