Survival outcome of iMB treated without adjuvant craniospinal irradiation: a pooled data analysis in the molecular era

We wish to describe the progression-free survival and overall survival of infants and young children with molecularly characterized medulloblastoma treated without upfront CSI. In addition, we wishe to describe the potential prognostics factors including clinical, treatment intensity, molecular subgroup, molecular subtype, and pathologic variables associated with progression-free survival. Finally, we wish to describe the pattern of relapse after initial radiation sparing strategies by molecular subgroup