T cell Receptor Therapies for pediatric High-Grade Gliomas

CBTN Research Resources are invaluable to pediatric HGG research. Patient derived cell lines 7316-158 and 7316-5317 whose diagnosis and subsequent relapse tumors have the H3 G34R mutation. This rare tumor mutation is the focus of our laboratory research. We seek to understand the consequences of the H3 G34R/V mutations that characterize these tumors, in relation to the ATRX/DAXX and Trp53 mutations that occur concurrently. Additionally, we seek to identify TCR targets derived from alternative mRNA processing as a source of cancer-specific epitopes in DHG.