Targeting Immunosuppressive Macrophage in Pediatric Brain Tumors

Macrophages are specialized immune cells involved in the detection and destruction of bacteria and other harmful organisms in the body. Tumor-associated macrophages (TAM) are immune cells found in solid tumors and these macrophages are believed to contribute to the growth and expansion of tumors including metastasis into the spinal cord. Therefore, TAMs represent possible targets in the treatment of pediatric brain cancers. Researchers seek to analyze data provided through the Pediatric Brain Tumor Atlas to understand the prevalence of TAMs in various cancer types. Through comparison of this data with patterns of cancer progression, researchers hope to identify new targets for the application of therapies.