Characterization Of Aberrant Splicing In Pediatric Central Nervous System Tumors Reveals Clk1 As A Candidate Oncogenic Dependency

Pediatric brain cancer is the leading cause of disease-related mortality in children, yet many aggressive tumors lack effective therapies. Aberrant RNA splicing is a hallmark of cancer, but its role in pediatric central nervous system (CNS) tumors remains underexplored.