The Landscape Of Primary Mismatch Repair Deficient Gliomas In Children, Adolescents, And Young Adults: A Multi-Cohort Study

Gliomas are a major cause of cancer-related death among children, adolescents, and young adults (age 0-40 years). Primary mismatch repair deficiency (MMRD) is a pan-cancer mechanism with unique biology and therapeutic opportunities. We aimed to determine the extent and impact of primary MMRD in gliomas among children, adolescents, and young adults.