Novel Fgfr2-Ina Fusion Identified In Two Low-Grade Mixed Neuronal-Glial Tumors Drives Oncogenesis Via Mapk And Pi3K/Mtor Pathway Activation

As a group, mixed neuronal-glial tumors (MNGTs) exhibit genetic variability, including stable genomes, whole chromo- some gains, BRAF-V600E, and FGFR1 mutations. While histologic criteria are described to distinguish MNGT types ganglioglioma (GG) and dysembryoplastic neuroepithelial tumor (DNT), non-specific features preclude confident classification in a high proportion of cases. Herein, we report the characterization of a novel FGFR2-INA fusion gene identified during clinical genomic profiling in two cases of MNGTs that could not be specifi- cally classified as GG or DNT.