Characterizing ATRT subtype evolution

Central nervous system (CNS) tumors are the leading cause of death by disease in children, and our lab is dedicated to advancing treatments for the most aggressive forms, including Atypical Teratoid Rhabdoid Tumors (ATRTs). This project will pilot single-cell resolution analyses of splicing and transcriptomic profiles in two pairs of longitudinal tumor samples, enabling us to track how these molecular features change over time. By capturing dynamic alterations in gene expression and splicing at the single-cell level, we aim to uncover mechanisms driving tumor progression and identify time-dependent therapeutic targets.