Defining the Mutational Landscape of Pediatric Brain Tumors

Understanding the mutational landscape of pediatric brain cancers, gene mutations and their significance in the growth of tumors, is pivotal in developing new treatments. Researchers seek to identify tissue specific changes and pleiotropic alterations, or multiple effects that can arise from a single gene, across pediatric brain tumor types. Such information will be important in the ongoing development of diagnoses, treatments, and assessments. Using the Pediatric Brain Tumor Atlas, researchers will perform initial analysis on Whole Genome Sequencing and RNA sequencing data, comprehensive genetic information that has been gathered across tumor types to complete this work.