A Highly-Usable and Fully-Comprehensive Proteogenomic Method Leveraging the Breadth of Genetic Variation for Oncogenic and/or Therapeutic Novel Protein Discovery

The development of many cancers is known to be driven by genetic rearrangements. Many of these genetic rearrangements can be caused by transposons, DNA sequences that can change position and move to other positions within the genome. In previous studies, one of these genes, human piggyBac transposable element derived 5 (PGBD5), was examined for its possible role in the development of brain cancers. In this study, researchers will further explore the role of PGBD5 in the development of pediatric brain cancers. Proteogenomics, which combines the study of genetic, protein, and transcription data to optimize success in protein discovery, is the focus of this project. Protein discovery will help researchers understand what role PGBD5 plays in the development of brain cancers and provides researchers with further targets for investigation. Researchers will incorporate the unique and comprehensive dataset available through the Pediatric Brain Tumor Atlas to expand their research across pediatric brain cancer types. Researchers on this project have developed new sophisticated methods to complete a customized investigation approach, which could be pivotal in the development of personalized therapies