Aberrant splicing candidates as potential neoantigen expression in HGG

The objective of this project is to investigate whether aberrant splicing candidates resulting from transcriptome-wide dysregulation of alternative splicing in high grade gliomas (HGGs) could be a source for novel neoantigen expression in tumors, that are distinct from missense mutations. We will leverage large-scale multi-omics datasets with state-of-the-art technologies to inform novel targets for CAR T-cell therapy, ultimately aiding in improving survival outcomes.