Searching for Differences in Molecular Profile of Pediatric Gliomas

Glioma is a type of brain cancer in which glial cells, a specific type of cell in the brain, become cancerous. In this study, researchers will examine how the DNA in glioma cells varies between different groups of patients and how these differences in DNA affect gene expression. This will allow for a greater understanding of how pediatric glioma develops, how it differs between patients, and how childhood glioma differs from adult glioma. To complete this research, RNA sequencing data from pediatric high grade gliomas (pHGGs) will be used to examine glioma gene expression. Particularly, researchers are searching for previously uncharacterized subtypes of pHGG. Understanding the similarities and differences of these subtypes could lead to more accurate diagnosis and more effective cancer therapies. Data from the Pediatric Brain Tumor Atlas, specifically the RNA sequencing data from pHGG samples, will be integral to the characterization of pHGG in this study.