Alternative Splicing in CBTN Data

Alternative splicing of RNA is the process that changes information from genes into proteins that can be used by a cell. Alternative splicing plays a critical role in the regulation of gene expression and protein diversity found within a cell, and understanding its function across pediatric tumors could lead to the identification of new therapeutic targets.The long-term objective of this project is to use the data from the Pediatric Brain Tumor Atlas to study alternative splicing in pediatric brain tumor transcriptome. Researchers plan to use the comprehensive data provided by the Pediatric Brain Tumor Atlas to develop new computational and statistical methods for quantifying alternative splicing events in large datasets, propelling the search for new treatments forward.