Discover New Therapeutics for DIPG using a Systems-Based Approach

Diffuse intrinsic pontine glioma (DIPG) is an aggressive type of brainstem cancer that targets young children. Complete surgical removal is not possible, and chemotherapy and radiotherapy are currently only effective in controlling pain and discomfort. New therapies are greatly needed to combat the poor prognosis of this cancer but they can not be developed without further research. While sequencing DNA gives a genetic profile of a tumor, sequencing RNA reflects only the sequences that are actively expressed in the cells leading researchers to new possible therapeutic targets. Therefore, researchers on this project will be analyzing the RNA sequencing data from pediatric brain cancer patients. Researchers will expand their current sample size with access to RNA sequencing data from the Pediatric Brain Tumor Atlas.