Analysis of chromatin pathways as regulators of high grade glioma gene expression patterns

To goal of our research is identify genes that are up- and down-regulated in brain tumors compared to normal tissue samples and genes that are up- and down-regulated in brain tumors with different mutations. We will compare these patient-derived gene expression profiles to data we have generated using human brain cancer cells grown in the lab that have either been genetically manipulated, or treated with various drugs. By analyzing and comparing patient and laboratory datasets we hope to identify gene expression patterns characteristic of different subsets of pediatric brain tumors, and to investigate the potential consequences of our genetic manipulation and drug treatment studies, which could provide a theoretical basis for the development of new therapies.