Cancer Predisposition in Pediatric Brain Tumors

Some children with brain tumors have changes in genes leading to an increased likelihood of tumor development. These are changes that are either inherited, or new to the child. We would like to query the CBTTC germline (blood) and somatic (tumor) DNA data to identify cancer predisposing variants, and compare these findings to clinical data, in order to better understand the reason that these tumors develop