Cracking the Histone Code: Characterizing Pediatric Brain Tumor Epigenetics using Cerebrospinal Fluid

Matched CSF and tumor tissue protein specimens from children with brain tumors are required to conduct the proposed research. A query of CBTTC database identified 84 subjects with available tumor tissue and CSF and 38 tumor tissue specimens for which our institution has matched CSF on hand (See Harvest Report). To further strengthen our approach we also request CSF from 10 additional subjects for whom matched tissue is not available. This large cohort of rare matched specimens will allow us to generate a significant amount of data to demonstrate the utility and biological relevance of this approach, laying the foundation for clinical translation of our findings.