Decoding the Dark Matter of the High-Risk Paediatric Cancer Genome

High-risk paediatric cancers have dismal survival rates, and despite best efforts using advanced DNA sequencing, we find very few mutations to explain this aggressiveness. We reasoned that whole classes of under-explored mutations in the “noncoding genome” may explain their poor outcomes, and we propose innovative ways to study these in the largest study of patients with these cancers to date.