Defining the mutational landscape of pediatric brain tumors

The objective of this study is to perform a primary analysis of recently-generated whole genome sequencing (WGS) of tumor-normal pairs and matched RNA-sequencing within the CBTTC. Our goal is to define the mutational landscape across the diverse cancers sequenced and to identify pleotropic and/or histotypes-specific alterations driving the development and progression of central nervous system cancers in pediatric populations. All variant files will be put into vcf or maf format and placed into a database that will accessible to approved researchers through the consortium.