Defining the role of the histone 3 (H3.3G34R) mutation in the pathogenesis of pediatric high astrocytoma

The patient derived cell lines will be used to validate the findings from our BioID screen. They will be essential in that they represent an endogenously expressing H3.3G34R mutant line. Further, they will be critical for determining the clinical significance of our findings and for testing potential novel therapeutic approaches.