Elucidate potential therapeutic targets in H3.3G34 mutant pHGG cells

Currently, we are only aware one H3.3G34V line. The precious lines you generated are extremely useful for the studies. The biospecimens and patient derived tumor models are greatly useful for the basic and translational research in understanding the mechanism of the disease thus helping develop effective therapeutically method (3). The H3.3G34R cell line will be useful for us to study the function of genes we identified. Therefore, we propose this study as a collaborative study with Dr. Cole if we receive the lines and obtain publishable results using the lines.