Developing Summative Measures of Paediatric Cancer Risk

Understanding the genetic reasons why some families develop cancer at a young age is critical for effective screening and identifying at-risk individuals. Currently, we mostly look at the effect of individual mutations in well-known cancer genes to determine a patient’s likely cancer risk. Here, we propose to develop new methods which look at far more genes and alternative signals in the data which we believe will lead to better ways of predicting cancer risk.