Genetic Architecture of Molecular Phenotypes in Pediatric Brain Cancers

Understanding the type of proteins that specific cancer cells produce can be useful in the identification and treatment of those cancers, but it is unknown to what degree protein expression of pediatric brain cancers are under germline genetic control. Using the Pediatric Brain Tumor Atlas, researchers aim to identify, compare, and contrast variations in and mechanisms for protein expression across many individual brain cancer types. This will serve as an important resource on the genetic control of protein expression, further guiding medical professionals on drug response and clinical outcomes.