Sex-specific Gene Expression Signatures in Pediatric Brain Tumors

Normal human development, disease risk, and response to treatments are often different in males and females. Cancer is no exception, and researchers are working to determine whether cancer treatments should be optimized independently for males and females. The goals of this project are to study the different mechanisms involved in male and female in pediatric neuroblastoma development and to further the knowledge of the genetic mechanisms involved in the development of cancers in both children and adults. The analysis of the Pediatric Brain Tumor Atlas data will be a critical component of moving this important line of investigation forward as it applies to the pediatric brain cancer population.