Investigating the etiology of genomic rearrangements in human cancers

Pediatric cancers are highly enriched with leukemias. We have enrolled >3000 leukemia samples. On the other hand, brain tumors and solid tumors are underrepresented due to lower incidence rate (we currently have ~1500 pediatric brain tumor/solid tumor samples). The addition of 867 brain tumors from CBTN will enhance our power of discovery and also allow us to validate our findings in our existing cohort.