Mechanistic Modeling of High-grade Glioma

This project is part of the EU funded project “individualized paediatric cure- iPC” that aims to find novel therapeutic routes for children with cancer. Researchers will carry out this work based on systems biological analysis and modeling of large scale genomic, transcriptomic and proteomic data sets. This makes this project a very comprehensive review of cancer systems. Data from patients with high grade gliomas will be made accessible to researchers through the Pediatric Brain Tumor Atlas. Researchers will model drug responses of an initial cohort of ~20 patients using a computer model to find potential drug treatments for high grade glioma patients. The information gained from this work will advance treatment options for patients with pediatric high grade gliomas.