Molecular Analysis of the Cellular Ecosystem of Childhood Ependymoma

Although they led to interesting and novel results, our preliminary analyses (Fig. 1) are limited by the lack of longitudinal single-cell expression data of ependymal tumors. Childhood ependymomas are rare tumors (4.6 new cases/year per 100,000 children15). To our knowledge, CBTTC is the only biorepository with a sufficiently large collection of flash-frozen specimens of primary, recurrent, and metastatic childhood ependymomas to perform this study. Additionally, the physical proximity to CHOP makes collaboration with CBTTC optimal.