Therapeutic targeting of the blood-brain barrier in pediatric malignant brain tumors

CBTTC source provides a uniform database of optimized tissue with highly notated data regarding clinical specimens, location, and associated therapies. At the NIH, we do not have a large clinical sample database for translational studies. Thus, use of CBTTC specimens and data will allow us to evaluate BBB restrictions related to treatment response with bioinformatic data mining, in culture and with rodent tumor models.