Imipridones Affect Tumor Bioenergetics And Promote Cell Lineage Differentiation In Diffuse Midline Gliomas

Pediatric diffuse midline gliomas (DMGs) are incurable childhood cancers. Imipridones are chemical compounds used to treat cancers orally. The imipridone ONC201 has shown early positive effects on DMGs. However, the anticancer mechanisms of ONC201 and its derivative ONC206 have not been fully described in this type of tumor. Researchers in this study found that chemicals targeting mitochondrial metabolism and ISR activation effectively impairs DMG growth. These results further support the use of imipridone ONC201 to treat pediatric DMGs.

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Imipridones Affect Tumor Bioenergetics And Promote Cell Lineage Differentiation In Diffuse Midline Gliomas

Previous PostRetrospective Dataset And Survey Analyses Identify Gaps In Data Collection For Craniopharyngioma And Priorities Of Patients And Families Affected By The Disease

Next PostProteogenomic Discovery of Neoantigens Facilitates Personalized Multi-antigen Targeted T Cell Immunotherapy for Brain Tumors

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